Smell identification in individuals at clinical high risk for schizophrenia

PSYCHIATRY RESEARCH

卷:220

Article

Gill, Kelly Elizabeth¹  Evans, Elizabeth¹  Kayser, Juergen¹  Ben-David, Shelly²  Messinger, Julie³  Bruder, Gerard¹  Malaspina, Dolores³  Corcoran, Cheryl Mary¹ 

[1] Columbia Univ, New York State Psychiat Inst, Dept Psychiat, New York, NY 10032 USA

[2] NYU, Sch Social Work, New York, NY 10003 USA

[3] NYU, Dept Psychiat, New York, NY 10016 USA

关键词: Olfaction;    Odor;    Ultra high risk;    Prodrome;    Prodromal;    Schizophrenia;    Negative symptoms;   

DOI  :  10.1016/j.psychres.2014.07.018

来源: Elsevier

【 摘 要 】

Smell identification deficits exist in schizophrenia, and may be associated with its negative symptoms. Less is known about smell identification and its clinical correlates in individuals at clinical high risk (CHR) for schizophrenia and related psychotic disorders. We examined smell identification, symptoms and IQ in 71 clinical high-risk (CHR) subjects and 36 healthy controls. Smell identification was assessed using both the 40-item University of Pennsylvania Smell Identification Test (UPSIT; Doty, R.L., Shaman, P., Kimmelman, C.P., Dann, M.S., 1984. University of Pennsylvania Smell Identification Test: a rapid quantitative olfactory function test for the clinic. Laryngoscope 94,176-178) and its extracted 12-item Brief Smell Identification Test (Goudsmit, N., Coleman, E., Seckinger, R.A., Wolitzky, R., Stanford, AD., Corcoran, C., Goetz, R.R., Malaspina, D., 2003. A brief smell identification test discriminates between deficit and non-deficit schizophrenia. Psychiatry Research 120,155-164). Smell identification did not significantly differ between CHR subjects and controls. Among CHR subjects, smell identification did not predict schizophrenia (N=19; 27%) within 2 years, nor was it associated with negative or positive symptoms. This is the third prospective cohort study to examine smell identification in CHR subjects, and overall, findings are inconclusive, similar to what is found for other disorders in adolescents, such as autism spectrum, attention deficit and anxiety disorders. Smell identification deficit may not have clear utility as a marker of emergent schizophrenia and related psychotic disorders. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

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