Apathy, poor verbal memory and male gender predict lower psychosocial functioning one year after the first treatment of psychosis

PSYCHIATRY RESEARCH

卷:210

Article

Faerden, Ann¹  Barrett, Elizabeth Ann¹  Nesvag, Ragnar²  Friis, Svein^1,3  Finset, Arnstein⁴  Marder, Stephen R.^5,6  Ventura, Joseph⁵  Andreassen, Ole A.^1,3  Agartz, Ingrid^2,3  Melle, Ingrid^1,3 

[1] Oslo Univ Hosp, N-0407 Oslo, Norway

[2] Diakonhjemmet Hosp, N-0319 Oslo, Norway

[3] Univ Oslo, Inst Clin Med, N-0318 Oslo, Norway

[4] Univ Oslo, Inst Behav Sci Med, N-0317 Oslo, Norway

[5] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Behav Sci, Los Angeles, CA 90095 USA

[6] VISN 22 Mental Illness Res Educ & Clin Ctr, Dept Vet Affairs, Los Angeles, CA USA

关键词: Psychosis;    Functional outcome;    Predictors;    Apathy;    Verbal memory;    Male gender;    Negative symptoms;   

DOI  :  10.1016/j.psychres.2013.02.007

来源: Elsevier

【 摘 要 】

Background: Apathy is a negative symptom associated with poor psychosocial functioning in schizophrenia but has not been sufficiently studied as predictor of poor functioning in first episode psychosis (FEP). Objective: The main aim of the current study was to evaluate if apathy predicts poor functioning after 1 year in FEP patients in the context of other clinical variables with influence on outcome. Method: Sixty-four FEP patients completed an extensive clinical and neuro-psychological test battery at baseline and 1-year follow-up. Symptoms were assessed with the Positive and Negative Syndrome scale (PANSS), apathy with the shortened Apathy Evaluation Scale (AES-C-12) and psychosocial functioning with the functioning score from the split version of the Global Assessment of Functioning scale (GAF-F). Results: High levels of apathy, poor verbal memory and being male were the baseline variables that best predicted poor functioning at 1-year follow-up, explaining 34% of the variance in GAF-F. When PANSS negative factor was included in the analysis, the significance of AES-C-12 diminished. Conclusion: These findings points to a robust role for apathy among the negative symptoms in the development of persisting psychosocial dysfunction in FEP and supports the current effort in targeting motivation to improve functioning. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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