Clinical investigation of set-shifting subtypes in anorexia nervosa

PSYCHIATRY RESEARCH

卷:219

Article

Abbate-Daga, Giovanni¹  Buzzichelli, Sara¹  Marzola, Enrica¹  Amianto, Federico¹  Fassino, Secondo¹ 

[1] Univ Turin, Dept Neurosci, Eating Disorders Ctr Treatment & Res, Turin, Italy

关键词: Eating disorders;    Anorexia nervosa;    Cognitive flexibility;    Interoceptive awareness;    Personality;    Neuropsychology;   

DOI  :  10.1016/j.psychres.2014.06.024

来源: Elsevier

【 摘 要 】

While evidence continues to accumulate on the relevance of cognitive inflexibility in anorexia nervosa (AN), its clinical correlates remain unclear. We aimed at examining the relationship between set-shifting and clinical variables (i.e., eating psychopathology, depression, and personality) in AN. Ninety-four individuals affected by AN and 59 healthy controls (HC) were recruited. All participants were assessed using: Eating Disorders Inventory-2 (EDI-2), Temperament and Character Inventory (TCI), Beck Depression Inventory (BDI), and Wisconsin Card Sorting Test (WCST). The AN group scored worse than HCs on set-shifting. According to their neuropsychological performances, AN patients were split into two groups corresponding to poor (N=30) and intact (N=64) set-shifting subtypes. Interoceptive awareness, impulse regulation, and maturity fears on the EDI-2 and depression on the BDI differed across all groups (HC, intact, and poor set-shifting subtype). Self-directedness on the TCI differed significantly among all groups. Cooperativeness and reward dependence differed instead only between HC and AN poor set-shifting subtype. After controlling for depression, only interoceptive awareness remained significant with reward dependence showing a trend towards statistical significance. These findings suggest that multiple clinical variables may be correlated with set-shifting performances in AN. The factors contributing to impaired cognitive inflexibility could be more complex than heretofore generally considered. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

Free