Assessing blinding in trials of psychiatric disorders: A meta-analysis based on blinding index

PSYCHIATRY RESEARCH

卷:219

Review

Freed, Brian^1,2  Assall, Oliver Paul³  Panagiotakis, Gary^1,2  Bang, Heejung⁴  Park, Jongbae J.^5,6  Moroz, Alex^1,2  Baethge, Christopher³ 

[1] NYU, Sch Med, Ctr Musculoskeletal Care, New York, NY 10016 USA

[2] NYU, Sch Med, Dept Rehabil Med, New York, NY 10016 USA

[3] Univ Cologne, Sch Med, Dept Psychiat & Psychotherapy, D-50931 Cologne, Germany

[4] Univ Calif Davis, Dept Publ Hlth Sci, Div Biostat, Davis, CA 95616 USA

[5] Univ N Carolina, Sch Med, Dept Phys Med & Rehabil, Chapel Hill, NC 27599 USA

[6] UNC Sch Dent, Ctr Pain Res & Innovat, Chapel Hill, NC 27599 USA

关键词: Methodology;    RCT;    Double-blind trials;    Blinded trials;    Schizophrenia;    Affective disorders;    Therapy;   

DOI  :  10.1016/j.psychres.2014.05.023

来源: Elsevier

【 摘 要 】

The assessment of blinding in RCTs is rarely performed. Currently most studies that do report data on evaluation of blinding merely report percentages of correct guessing, not taking into account correct guessing by chance. Blinding assessment using the blinding index (BI) has never been performed in a systematic review on studies of major psychiatric disorders. This study is a systematic review of psychiatric randomized control trials using the BI as a chance-corrected measurement of blinding, a tool to analyze and understand the patterns of blinding across studies of major psychiatric disorders with available data. Of 2467 psychiatric RD's from 2000 to 2010, 66 reported on blinding and 40 studies were found to have enough information on evaluation of blinding to be analyzed using the BI. The experimental treatment groups had an average BI value of 0.14 and the control groups had an average BI value of 0.00. The most common BI scenario was random random, indicating ideal blinding. A positive correlation between effect size and more correct guesses was also found. Overall, based on BI values and the most common blinding scenario, the published articles on major psychiatric disorders from 2000 to 2010, which reported on blinding assessment for patients, were effectively blinded. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

Free