The post illumination pupil response is reduced in seasonal affective disorder

PSYCHIATRY RESEARCH

卷:210

Article

Roecklein, Kathryn¹  Wong, Patricia¹  Ernecoff, Natalie¹  Miller, Megan¹  Donofry, Shannon¹  Kamarck, Marissa¹  Wood-Vasey, W. Michael²  Franzen, Peter³ 

[1] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA

[2] Univ Pittsburgh, Dept Phys & Astron, Pittsburgh, PA 15260 USA

[3] Univ Pittsburgh, Med Ctr, Dept Psychiat, Pittsburgh, PA 15260 USA

关键词: Seasonal affective disorder;    Melanopsin;    Pupillometry;   

DOI  :  10.1016/j.psychres.2013.05.023

来源: Elsevier

【 摘 要 】

Individuals with seasonal affective disorder (SAD) may have a decreased retinal sensitivity in the non-image forming light-input pathway. We examined the post illumination pupil response (PIPR) among individuals with SAD and healthy controls to identify possible differences in the melanopsin signaling pathway. We also investigated whether melanopsin gene (OPN4) variations would predict variability in the PIPR. Fifteen SAD and 15 control participants (80% women, mean age 36.7 years, S.D.=14.5) were assessed in the fall/winter. Participants were diagnosed based on DSM-IV-TR criteria. Infrared pupillometry was used to measure pupil diameter prior to, during, and after red and blue stimuli. In response to blue light, the SAD group had a reduced PIPR and a lower PIPR percent change relative to controls. The PIPR after the blue stimulus also varied on the basis of OPN4 I394T genotype, but not OPN4 P10L genotype. These findings may indicate that individuals with SAD have a less sensitive light input pathway as measured by the PIPR, leading to differences in neurobiological and behavioral responses such as alertness, circadian photoentrainment, and melatonin release. In addition, this sensitivity may vary based on sequence variations in OPN4, although a larger sample and replication is needed. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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