Cytomegalovirus infection and IQ in patients with severe mental illness and healthy individuals

PSYCHIATRY RESEARCH

卷:300

Article

Andreou, Dimitrios^1,2,3,4,5  Jogensen, Kjetil Nordb^1,5  Wortinger, Laura A.^1,5  Engen, Kristine^1,5  Vaskinn, Anja^1,6  Ueland, Torill^1,6,7  Yolken, Robert H.⁸  Andreassen, Ole A.^1,9  Agartz, Ingrid^1,2,3,5 

[1] Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, Oslo, Norway

[2] Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden

[3] Stockholm Cty Council, Stockholm Hlth Care Serv, Stockholm, Sweden

[4] Natl & Kapodistrian Univ Athens, Dept Psychiat 1, Athens, Greece

[5] Diakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway

[6] Oslo Univ Hosp, Psychosis Res Sect, Oslo, Norway

[7] Univ Oslo, Dept Psychol, Oslo, Norway

[8] Johns Hopkins Univ, Sch Med, Dept Pediat, Stanley Div Dev Neurovirol, Baltimore, MD 21205 USA

[9] Oslo Univ Hosp, Div Mental Hlth & Addict, Norwegian Ctr Mental Disorders Res NORMENT, Oslo, Norway

关键词: Cytomegalovirus;    Intelligence;    IQ;    Schizophrenia;    Bipolar disorder;    Healthy individuals;   

DOI  :  10.1016/j.psychres.2021.113929

来源: Elsevier

【 摘 要 】

Cytomegalovirus (CMV) infection in immunocompetent adults is usually asymptomatic, but results in lifelong latency. Infection occurring congenitally or in immunodeficiency can lead to cognitive impairment. We aimed to investigate the associations between CMV exposure and intelligence quotient (IQ) in patients with schizophrenia spectrum disorders (SZS), bipolar spectrum disorders (BDS) and healthy controls (HC). CMV immunoglobulin G antibody concentrations were measured by immunoassay and expressed as dichotomous measures (seropositive/ CMV+ vs. seronegative/CMV-). Based on a significant CMV-by-diagnosis-by-sex interaction on IQ, we investigated main and interaction effects of CMV and sex on IQ in each diagnostic category. Significant CMV-by-sex interactions were found in patient groups. In SZS, CMV+ female patients (n = 50) had significantly lower IQ than CMV- female patients (n = 33), whereas CMV+ (n = 48) and CMV- (n = 45) male patients did not differ in IQ. In BDS, CMV+ (n = 49) and CMV- (n = 37) female patients did not differ in IQ, whereas CMV+ male patients (n = 33) had significantly higher IQ than CMV- male patients (n = 32). Among HC, CMV+ (n = 138) and CMV(n = 118) male participants as well as CMV+ (n = 125) and CMV- (n = 93) female participants did not differ in IQ. Our findings suggest that CMV exposure may affect IQ in patients with severe mental illness but not HC.

【 授权许可】

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