LATENCY TO RAPID EYE-MOVEMENT SLEEP AS A PREDICTOR OF TREATMENT RESPONSE TO FLUOXETINE AND PLACEBO IN NONPSYCHOTIC DEPRESSED OUTPATIENTS

PSYCHIATRY RESEARCH

卷:52

Article

HEILIGENSTEIN, JH ; FARIES, DE ; RUSH, AJ ; ANDERSEN, JS ; PANDE, AC ; ROFFWARG, HP ; DUNNER, D ; GILLIN, JC ; JAMES, SP ; LAHMEYER, H ; ZAJECKA, J ; TOLLEFSON, GD ; GARDNER, DM

关键词: AFFECTIVE DISORDER;    POLYSOMNOGRAPHY;    ANTIDEPRESSANT RESPONSE PREDICTION;   

DOI  :  10.1016/0165-1781(94)90078-7

来源: Elsevier

【 摘 要 】

Fluoxetine and placebo were compared in 89 outpatients with major depression with (n = 45) or without (n = 44) a reduced or shortened rapid eye movement latency (SREML) (less than or equal to 65 minutes) to determine whether rapid eye movement latency (REML) predicted placebo and/or antidepressant response. Men and women were stratified based on polysomnographic recordings and then randomly assigned to receive double-blind fluoxetine (20 mg/day) or placebo for 8 weeks after a 2-week, single-blind, placebo lead-in period. Fluoxetine-treated patients demonstrated a significantly greater reduction in the Hamilton Rating Scale for Depression total score and a significantly greater response rate than placebo-treated patients in both the SREML and the combined strata. Treatment differences in the non-SREML stratum were not statistically significant. Results supported REML as a predictor of placebo nonresponse but did not predict a differential fluoxetine response in patients with SREML compared with patients without SREML.

【 授权许可】

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