Acute effects of trauma-focused research procedures on participant safety and distress

PSYCHIATRY RESEARCH

卷:215

Article

Brown, Vanessa M.^1,2  Strauss, Jennifer L.^1,3,4  LaBar, Kevin S.^2,3  Gold, Andrea L.⁵  McCarthy, Gregory⁵  Morey, Rajendra A.^1,2,3 

[1] Durham VA Med Ctr, Mental Illness Res Educ & Clin Ctr Post Deploymen, Durham, NC USA

[2] Duke Univ, Duke UNC Brain Imaging & Anal Ctr, Durham, NC USA

[3] Duke Univ, Dept Psychiat & Behav Sci, Durham, NC USA

[4] Vet Adm Med Ctr, Ctr Hlth Serv Res Primary Care, Durham, NC 27705 USA

[5] Yale Univ, Dept Psychol, New Haven, CT 06520 USA

关键词: PTSD;    Trauma;    Research risks;    Risk assessment;    Suicidal ideation;    Homicidal ideation;    Distress;   

DOI  :  10.1016/j.psychres.2013.10.038

来源: Elsevier

【 摘 要 】

The ethical conduct of research on posttraumatic stress disorder (PTSD) requires assessing the risks to study participants. Some previous findings suggest that patients with PTSD report higher distress compared to non-PTSD participants after trauma-focused research. However, the impact of study participation on participant risk, such as suicidal/homicidal ideation and increased desire to use drugs or alcohol, has not been adequately investigated. Furthermore, systematic evaluation of distress using pre- and post-study assessments, and the effects of study procedures involving exposure to aversive stimuli, are lacking. Individuals with a history of PTSD (n=68) and trauma-exposed non-PTSD controls (n=68) responded to five questions about risk and distress before and after participating in research procedures including a PTSD diagnostic interview and a behavioral task with aversive stimuli consisting of mild electrical shock. The desire to use alcohol or drugs increased modestly with study participation among the subgroup (n=48) of participants with current PTSD. Participation in these research procedures was not associated with increased distress or participant risk, nor did study participation interact with lifetime PTSD diagnosis. These results suggest some increase in distress with active PTSD but a participant risk profile that supports a favorable risk-benefit ratio for conducting research in individuals with PTSD. Published by Elsevier Ireland Ltd.

【 授权许可】

Free