Psychosocial functioning, quality of life and clinical correlates of comorbid alcohol and drug dependence syndromes in people with schizophrenia across Europe

PSYCHIATRY RESEARCH

卷:239

Article

Carra, Giuseppe¹  Johnson, Sonia¹  Crocamo, Cristina²  Angermeyer, Matthias C.³  Brugha, Traolach⁴  Azorin, Jean-Michel⁵  Toumi, Mondher⁶  Bebbington, Paul E.¹ 

[1] UCL, Div Psychiat, 6th Floor,Maple House,149 Tottenham Court Rd, London W1T 7NF, England

[2] Univ Pavia, Unit Biostat & Clin Epidemiol, Dept Publ Hlth Expt & Forens Med, Via Forlanini 2, I-27100 Pavia, Italy

[3] Univ Leipzig, Dept Psychiat, Johannisallee 20, D-04137 Leipzig, Germany

[4] Univ Leicester, Dept Hlth Sci, 22-28 Princess Rd West, Leicester LE1 6TP, Leics, England

[5] Hop St Marguerite, SHU Psychiat Adultes, F-13274 Marseille 9, France

[6] Univ Lyon 1, UFR Odontol, Chair Market Access, 11 Rue Guillaume Paradin, F-69008 Lyon, France

关键词: Schizophrenia;    Alcohol dependence;    Drug dependence;    Comorbidity;   

DOI  :  10.1016/j.psychres.2016.03.038

来源: Elsevier

【 摘 要 】

Little is known about the correlates of comorbid drug and alcohol dependence in people with schizophrenia outside the USA. We tested hypotheses that dependence on alcohol/drugs would be associated with more severe symptoms, and poorer psychosocial functioning and quality of life. The EuroSC Cohort study (N=1204), based in France, Germany and the UK, used semi-structured clinical interviews for diagnoses, and standardized tools to assess correlates. We used mixed models to compare outcomes between past-year comorbid dependence on alcohol/drugs, controlling for covariates and modelling both subject and country-level effects. Participants dependent on alcohol or drugs had fewer negative symptoms on PANSS than their non-dependent counterparts. However, those dependent on alcohol scored higher on PANSS general psychopathology than those who were not, or dependent only on drugs. People with schizophrenia dependent on drugs had poorer quality of life, more extrapyramidal side effects, and scored worse on Global Assessment of Functioning (GAF) than those without dependence. People with alcohol dependence reported more reasons for non-compliance with medication, and poorer functioning on GAF, though not on Global Assessment of Relational Functioning. In people with schizophrenia, comorbid dependence on alcohol or drugs is associated with impaired clinical and psycho social adjustment, and poorer quality of life. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

Free