Exploration of NO2 and PM2.5 air pollution and mental health problems using high-resolution data in London-based children from a UK longitudinal cohort study

PSYCHIATRY RESEARCH

卷:272

Article

Roberts, Susanna¹  Arseneault, Louise¹  Barratt, Benjamin²  Beevers, Sean²  Danese, Andrea^1,3,4  Odgers, Candice L.^5,6  Moffitt, Terrie E.^1,7,8,9,10  Reuben, Aaron^7,8,9,10  Kelly, Frank J.²  Fisher, Helen L.¹ 

[1] Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, 16 De Crespigny Pk, London SE5 8AF, England

[2] Kings Coll London, Environm Res Grp, MRC PHE Ctr Environm & Hlth, London, England

[3] Kings Coll London, Dept Child & Adolescent Psychiat, Inst Psychiat Psychol & Neurosci, London, England

[4] South London & Maudsley NHS Fdn Trust, Natl & Specialist CAMHS Clin Trauma Anxiety & Dep, London, England

[5] Duke Univ, Sanford Sch Publ Policy, Durham, NC USA

[6] Univ Calif Irvine, Dept Psychol & Social Behav, Irvine, CA USA

[7] Duke Univ, Dept Psychol, Durham, NC 27706 USA

[8] Duke Univ, Dept Neurosci, Durham, NC USA

[9] Duke Univ, Dept Psychiat & Behav Sci, Durham, NC USA

[10] Duke Univ, Ctr Genom & Computat Biol, Durham, NC USA

关键词: ADHD;    Anxiety;    Conduct disorder;    Depression;    Environment;    Neighbourhood;    Psychiatric;    Psychopathology;   

DOI  :  10.1016/j.psychres.2018.12.050

来源: Elsevier

【 摘 要 】

Air pollution is a worldwide environmental health issue. Increasingly, reports suggest that poor air quality may be associated with mental health problems, but these studies often use global measures and rarely focus on early development when psychopathology commonly emerges. To address this, we combined high-resolution air pollution exposure estimates and prospectively-collected phenotypic data to explore concurrent and longitudinal associations between air pollutants of major concern in urban areas and mental health problems in childhood and adolescence. Exploratory analyses were conducted on 284 London-based children from the Environmental Risk (E-Risk) Longitudinal Twin Study. Exposure to annualized PM2.5 and NO2 concentrations was estimated at address-level when children were aged 12. Symptoms of anxiety, depression, conduct disorder, and attention deficit hyperactivity disorder were assessed at ages 12 and 18. Psychiatric diagnoses were ascertained from interviews with the participants at age 18. We found no associations between age-12 pollution exposure and concurrent mental health problems. However, age-12 pollution estimates were significantly associated with increased odds of major depressive disorder at age 18, even after controlling for common risk factors. This study demonstrates the potential utility of incorporating high-resolution pollution estimates into large epidemiological cohorts to robustly investigate associations between air pollution and youth mental health.

【 授权许可】

Free