Negative affect predicts social functioning across schizophrenia and bipolar disorder: Findings from an integrated data analysis

PSYCHIATRY RESEARCH

卷:243

Article

Grove, Tyler B.¹  Tso, Ivy F.^1,2  Chun, Jinsoo³  Mueller, Savanna A.¹  Taylor, Stephan F.²  Ellingrod, Vicki L.⁴  McInnis, Melvin G.¹  Deldin, Patricia J.^1,2 

[1] Univ Michigan, Dept Psychol, East Hall,530 Church St, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA

[3] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Boston, MA USA

[4] Univ Michigan, Coll Pharm, 428 Church St, Ann Arbor, MI 48109 USA

关键词: Emotion;    Serious mental illness;    Transdiagnostic;    Cognition;    Social cognition;    Positive symptoms;    Negative symptoms;   

DOI  :  10.1016/j.psychres.2016.06.031

来源: Elsevier

【 摘 要 】

Most people with a serious mental illness experience significant functional impairment despite ongoing pharmacological treatment. Thus, in order to improve outcomes, a better understanding of functional predictors is needed. This study examined negative affect, a construct comprised of negative emotional experience, as a predictor of social functioning across serious mental illnesses. One hundred twenty-seven participants with schizophrenia, 113 with schizoaffective disorder, 22 with psychosis not otherwise specified, 58 with bipolar disorder, and 84 healthy controls (N=404) completed self-report negative affect measures. Elevated levels of negative affect were observed in clinical participants compared with healthy controls. For both clinical and healthy control participants, negative affect measures were significantly correlated with social functioning, and consistently explained significant amounts of variance in functioning. For clinical participants, this relationship persisted even after accounting for cognition and positive/negative symptoms. The findings suggest that negative affect is a strong predictor of outcome across these populations and treatment of serious mental illnesses should target elevated negative affect in addition to cognition and positive/negative symptoms. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

Free