Short communication: Diffusion tensor anisotropy in the cingulate in borderline and schizotypal personality disorder

PSYCHIATRY RESEARCH

卷:279

Article

Goldstein, Kim E.^1,2  Haznedar, M. Mehmet^1,3  Alloy, Lauren B.⁴  Drabick, Deborah A. G.⁴  McClure, Margaret M.¹  New, Antonia S.^1,2  Chu, King-Wai²  Vaccaro, Daniel^1,2  Tang, Cheuk Y.⁵  Meyerson, David¹  Hazlett, Erin A.^1,2 

[1] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA

[2] James J Peters VA Med Ctr, Mental Illness Res Educ & Clin Ctr MIRECC VISN2, 130W,Kingsbridge Rd,Rm 6A-45, Bronx, NY 10468 USA

[3] James J Peters VA Med Ctr, Outpatient Psychiat, Bronx, NY USA

[4] Temple Univ, Dept Psychol, Philadelphia, PA 19122 USA

[5] Icahn Sch Med Mt Sinai, Dept Radiol, New York, NY 10029 USA

关键词: Borderline personality disorder;    Schizotypal personality disorder;    Diffusion tensor imaging;   

DOI  :  10.1016/j.psychres.2019.05.016

来源: Elsevier

【 摘 要 】

Despite considerable phenomentological differences between borderline personality disorder (BPD) and schizotypal personality disorder (SPD), research increasingly provides evidence that some BPD symptoms overlap with SPD symptoms (e.g., disturbed cognitions). We examined the cingulate, a brain region implicated in the pathophysiology of both disorders, to determine similarities/differences between the groups, and similarities/differences from healthy controls (HC's). 3T structural and diffusion tensor magnetic resonance imaging scans were acquired in BPD (n = 27), SPD (n = 32), HC's (n = 34). Results revealed that BPD patients exhibited significantly lower FA in posterior cingulate white matter compared to HC's (p = 0.04), but SPD patients did not.

【 授权许可】

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