Autonomic arousal profiles in adolescents and young adults with ADHD as a function of recording context

PSYCHIATRY RESEARCH

卷:275

Article

Du Rietz, Ebba¹  James, Sarah-Naomi²  Banaschewski, Tobias³  Brandeis, Daniel^3,4  Asherson, Philip¹  Kuntsi, Jonna¹ 

[1] Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, 16 De Crespigny Pk,Denmark Hill, London SE5 8AF, England

[2] UCL, MRC Unit Lifelong Hlth & Ageing, 33 Bedford Pl, London WC1B 5JU, England

[3] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Child & Adolescent Psychiat & Psychotherapy, Sq J5, D-68159 Mannheim, Germany

[4] Univ Zurich, Dept Child & Adolescent Psychiat, Neumunsterallee 9, CH-8032 Zurich, Switzerland

关键词: Tonic arousal;    Phasic arousal;    Electrodermal activity;    Skin conductance;    ADHD;   

DOI  :  10.1016/j.psychres.2019.03.039

来源: Elsevier

【 摘 要 】

A recent study (James et al. 2016) found that attention-deficit/hyperactivity disorder (ADHD) was associated with hypo-arousal, indexed by low electrodermal activity, during a low-demand reaction-time task, which normalized in a fast-incentive condition. We now investigate if (1) autonomic arousal in individuals with ADHD changes over a long testing session and (2) across time, to clarify if arousal profiles are context-dependent. We also examine (3) how autonomic arousal relates to each ADHD symptom domain, and specificity of arousal profiles to ADHD, by controlling for oppositional defiant/conduct disorder (ODD/CD) symptoms. Skin conductance level and non-specific fluctuations were measured during four successive resting-state and cognitive conditions (Resting-state time 1, Continuous Performance Task, Fast Task: Baseline and Fast-Incentive conditions, Resting-state time 2) from 71 adolescents/young adults with ADHD and 140 controls. Lower arousal was observed in individuals with ADHD only during a slow, low-demanding task, and more fluctuating arousal was observed towards the end of assessment. Both inattentive and hyperactive-impulsive symptoms were associated with arousal levels and fluctuations, independently from ODD/CD. Overall, we extend previous findings showing that under-arousal, but also fluctuating arousal, are context-specific rather than stable impairments in ADHD.

【 授权许可】

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