Cognitive remediation for adults with schizophrenia: Does age matter?

PSYCHIATRY RESEARCH

卷:247

Article

Corbera, Silvia^1,4,6  Wexler, Bruce E.⁴  Poltorak, Ania^5,7  Thime, Warren R.¹  Kurtz, Matthew M.^1,2,3,4 

[1] Inst Living, Schizophrenia Rehabil Program, Hartford, CT USA

[2] Wesleyan Univ, Dept Psychol, 207 High St, Middletown, CT 06459 USA

[3] Wesleyan Univ, Program Neurosci & Behav, Middletown, CT USA

[4] Yale Sch Med, Dept Psychiat, New Haven, CT USA

[5] Inst Living, Olin Neuropsychiat Res Ctr, Hartford, CT USA

[6] Cent Connecticut State Univ, New Britain, CT 06050 USA

[7] Univ St Joseph, Hartford, CT USA

关键词: Schizophrenia;    Cognitive remediation;    Age;    Early psychosis;    Working memory;   

DOI  :  10.1016/j.psychres.2016.10.084

来源: Elsevier

【 摘 要 】

Cognitive remediation (CR), a novel behavioral intervention designed to improve cognitive deficits through repeated task practice and/or strategy acquisition has gained increasing empirical support in people with schizophrenia, but substantial individual differences in treatment response remain (Wykes et al., 2011). The role of age on response to CR in schizophrenia remains understudied. We evaluated the role of three age ranges in treatment response to CR relative to a closely-matched computer skills control intervention in a blinded, randomized control trial (RCT) with 112 adults with schizophrenia divided into three groups: an early-stage group (ES; 25 years or younger, mean=3.4 years of illness; n=45), an early-chronic group (EC; 26-39, mean=7.6 years of illness; n=31) and a late-chronic group (LC; 40 and over, mean=18.2 years of illness; n=36). With respect to cognitive outcomes, early-stage and early-chronic individuals with schizophrenia showed greater improvement in response to CR on a working memory measure at a trend level, relative to late-chronic clients. These findings were confirmed in analyses of a subsample of clients who received an adequate dose of treatment. These findings emphasize the need for adaptations of currently-existing CR programs to more effectively address the needs of older client populations.

【 授权许可】

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