Frontolimbic brain volume abnormalities in bipolar disorder with suicide attempts

PSYCHIATRY RESEARCH

卷:294

Article

Jabbi, Mbemba^1,2,3,4  Weber, Wade^1,2  Welge, Jeffrey⁵  Nery, Fabiano⁵  Tallman, Maxwell⁵  Gable, Austin⁵  Fleck, David E.⁵  Lippard, Elizabeth T. C.^1,2,3,4  DelBello, Melissa⁵  Adler, Caleb⁵  Strakowski, Stephen M.^1,2,4 

[1] Univ Texas Austin, Dell Med Sch, Dept Psychiat, Austin, TX 78712 USA

[2] Univ Texas Austin, Dell Med Sch, Mulva Clin Neurosci, Austin, TX 78712 USA

[3] Univ Texas Austin, Inst Neurosci, Austin, TX 78712 USA

[4] Univ Texas Austin, Dept Psychol, Austin, TX 78712 USA

[5] Univ Cincinnati, Coll Med, Dept Psychiat & Behav Neurosci, Cincinnati, OH USA

关键词: Bipolar I Disorder;    Mood Status;    Suicide Attempt;    Gray Matter Volume;    Brain;    Behavior;   

DOI  :  10.1016/j.psychres.2020.113516

来源: Elsevier

【 摘 要 】

Over 2.3 million people in the United States live with bipolar disorder. Sixty percent of those with a bipolar disorder diagnosis attempt suicide at least once in their lifetime and up to 19% die by suicide. However, the neurobiology of suicide attempts in bipolar disorder remains unclear. We studied the gray matter volume (GMV) of 81 participants with a bipolar-I diagnosis (age-range: 14-34 years old) and 40 healthy participants (age-range 14.7-32 years old) to compare their neuroanatomy and histories of suicide attempt. In the bipolar group, 42 were manic with ages ranging from 14-30.6 years, and 39 were depressed with ages ranging from 14-34.3 years). Twenty three bipolar participants had a suicide attempt history, and 58 had no suicide attempt history. All participants completed behavioral/diagnostic assessments and MRI. We focused on a predefined frontolimbic circuitry in bipolar disorder versus controls to first identify diagnostic GMV correlates and to specifically identify GMV correlates for suicide attempt history. We found reduced GMV in bipolar diagnosis versus controls in the subgenual cingulate and dorsolateral prefrontal cortices. Our observed regional GMV reductions were associated with histories of suicide attempts and measures of individual variations in current suicidal ideation at the time of scanning.

【 授权许可】

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