Decreased suicidal ideation in depressed patients with or without comorbid posttraumatic stress disorder treated with selective serotonin reuptake inhibitors: An open study

PSYCHIATRY RESEARCH

卷:196

Article

Sher, Leo ; Stanley, Barbara H. ; Posner, Kelly ; Arendt, Mikkel ; Grunebaum, Michael F. ; Neria, Yuval ; Mann, Joseph John ; Oquendo, Maria A.

关键词: Posttraumatic stress disorder;    Major depressive disorder;    Suicidal ideation;    Selective serotonin reuptake inhibitors;   

DOI  :  10.1016/j.psychres.2011.11.010

来源: Elsevier

【 摘 要 】

Comorbidity of posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) is associated with higher morbidity including suicidal ideation and behavior. Selective serotonin reuptake inhibitors (SSRIs) are a known treatment for PTSD, MOD and comorbid PTSD and MDD. Since the patients with comorbid MOD and PTSD (PTSD-MDD) are sicker, we hypothesize a poorer response to treatment compared to patients with MOD only. Ninety-six MDD patients were included in the study: 76 with MDD only and 20 with PTSD-MDD. Demographic and clinical parameters at baseline were assessed. We examined clinical parameters before and after 3 months of open SSRI treatment in subjects with PTSD-MDD and compared this group to individuals with MDD only. At baseline, PTSD-MDD patients had higher Hamilton Depression Rating Scale and Buss-Durkee Hostility Scale scores compared with MOD only subjects. There was a significant decrease in scores on the Hamilton Depression Rating Scale, Beck Depression Inventory, Beck Hopelessness Scale, and Beck Scale for Suicidal Ideation after 3 months of treatment with SSRIs in both groups. The magnitude of improvement in Beck Scale for Suicidal Ideation scores was greater in the PTSD-MDD group compared to the MDD only subjects. Symptoms of depression including suicidal ideation improved in MDD patients with or without comorbid PTSD after 3 months of treatment with SSRIs but improvement in suicidal ideation was greater in the PTSD-MDD group. Our finding has not supported the hypothesis that a response to treatment is poorer in the PTSD-MDD group which may indicate that sicker patients benefit more from the treatment. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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