Increased oxidative stress in patients with depression and its relationship to treatment

PSYCHIATRY RESEARCH

卷:206

Article

Chung, Cecilia P.¹  Schmidt, Dennis³  Stein, Charles Michael^1,2  Morrow, Jason D.^1,2  Salomon, Ronald M.³ 

[1] Vanderbilt Univ, Sch Med, Dept Med, Nashville, TN 37212 USA

[2] Vanderbilt Univ, Sch Med, Dept Pharmacol, Nashville, TN 37212 USA

[3] Vanderbilt Univ, Sch Med, Dept Psychiat, Nashville, TN 37212 USA

关键词: Depression;    Oxidative stress;    F2 isoprostanes;    Antidepressants;    Sertraline;    Bupropion;   

DOI  :  10.1016/j.psychres.2012.10.018

来源: Elsevier

【 摘 要 】

Oxidative stress may play a role in the pathogenesis of depression. We tested the hypothesis that urinary F2 isoprostanes, a robust marker of oxidative stress, was increased in patients with depression and associated with symptoms and response to treatment. Urinary F2 isoprostanes was compared in 18 patients with depression and 36 age and sex matched control subjects. In patients, we tested the association between oxidative stress, depression questionnaires and antidepressant treatment. Urinary F2 isoprostane excretion was significantly higher in patients with depression than in control subjects. This association remained significant after adjustment for age, sex and BMI. Depression symptom severity scores were not correlated with F2 isoprostane excretion. Nine patients were treated with sertraline or bupropion for 8 weeks. Depression severity rating scale scores decreased significantly and F2 isoprostane excretion increased. The increase in F2 isoprostane excretion was inversely correlated with the improvement in Hamilton Depression Rating 17 items. In conclusion, oxidative stress is increased in patients with depression. However, although treatment with either bupropion or sertraline reduces the symptoms of depression, it may increase F2 isoprostane excretion. These results suggest that alternative mechanisms, beyond oxidative stress, may be involved in the development of depression and subsequent responses to treatment. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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