Correlates of vitamin D in psychotic disorders: A comprehensive systematic review

PSYCHIATRY RESEARCH

卷:249

Review

Adamson, James^1,2  Lally, John^1,2,3  Gaughran, Fiona^1,2  Krivoy, Amir^1,2  Allen, Lauren¹  Stubbs, Brendon^1,2 

[1] Kings Coll London, Inst Psychiat Psychol & Neurosci, Crespigny Pk, London SE5 8AF, England

[2] South London & Maudsley NHS Fdn Trust, London, England

[3] Beaumont Hosp, Royal Coll Surg Ireland, Dept Psychiat, Dublin, Ireland

关键词: Schizophrenia;    Psychosis;    Vitamin D;    Hypovitaminosis D;    25-hydroxyvitamin D;    25-OHD;   

DOI  :  10.1016/j.psychres.2016.12.052

来源: Elsevier

【 摘 要 】

People with psychosis have high prevalence of low vitamin D levels but the correlates and relevance of this deficiency are unclear. A systematic search of major databases from inception to 03/2016 was undertaken investigating correlates of vitamin D in people with psychosis. Data was summarised with a best evidence synthesis. Across 23 included studies (n=1770 psychosis, n=8171 controls) a mean difference in vitamin D levels between both groups of 11.14 ng/ml 0.59 was found. 53 unique correlations between vitamin D and outcomes in people with psychosis were identified. The evidence base was broadly equivocal although season of blood sampling (67% of studies found a positive correlation with warmer seasons) and parathyroid hormone (100% of studies found a negative correlation) were associated with vitamin D levels. The most commonly non correlated variables were: BMI (83% found no correlation), age (73%), gender (86%), smoking (100%), duration of illness (100%) and general assessment of functioning score (100%). In conclusion, whilst many unique correlates have been investigated, there is weak and inconclusive evidence regarding the consistency and meaning of the correlates of vitamin D levels in people with psychosis. Future longitudinal studies should consider the correlates of vitamin D in people with psychosis.

【 授权许可】

Free