Mortality in individuals with disruptive behavior disorders diagnosed by specialist services - A nationwide cohort study

PSYCHIATRY RESEARCH

卷:251

Article

Scott, James G.^1,2,3  Pedersen, Marianne Giortz^4,5  Erskine, Holly E.^1,2,6,7  Bikic, Aida^8,9  Demontis, Ditte^5,10  McGrath, John J.^2,4,11  Dalsgaard, Soren^4,5,12,13 

[1] Univ Queensland, UQ Ctr Clin Res, Herston, Qld 4029, Australia

[2] Queensland Ctr Mental Hlth Res, Pk Ctr Mental Hlth, Wacol, Qld 4076, Australia

[3] Royal Brisbane & Womens Hosp, Metro North Mental Hlth, Herston, Qld 4029, Australia

[4] Aarhus Univ, Sch Business & Social Sci, Dept Econ & Business, Natl Ctr Register Based Res, Aarhus, Denmark

[5] Lundbcck Fdn Initiat Integrat Psychiat Res, IPSYCH, Aarhus, Denmark

[6] Univ Queensland, Sch Publ Hlth, Herston, Qld 4006, Australia

[7] Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98195 USA

[8] Univ Southern Denmark, Inst Clin Res, Odense, Denmark

[9] Dept Child & Adolescent Mental Hlth Serv, Aabenraa, Region Southern, Denmark

[10] Aarhus Univ, Dept Biomed, Aarhus, Denmark

[11] Univ Queensland, Queensland Brain Inst, St Lucia, Qld 4076, Australia

[12] Aarhus Univ, CIRRAU Ctr Integrated Register Based Res, Aarhus, Denmark

[13] Hosp Telemark, Dept Child & Adolescent Psychiat, Telemark, Kragero, Norway

关键词: Disruptive behavior disorders;    Conduct disorder;    Oppositional defiant disorder;    Mortality;    Deaths;    Registries;    Epidemiology;   

DOI  :  10.1016/j.psychres.2017.02.029

来源: Elsevier

【 摘 要 】

Disruptive behavior disorders (DBDs), inclusive of oppositional defiant disorder (ODD) and conduct disorder (CD), are associated with outcomes likely to increase risk of mortality. Using Danish National Registers, a total of 1.92 million individuals including 9495 individuals with EBDs diagnosed by specialist services were followed from their first birthday to 2013. Those with and without DBDs were compared using mortality rate ratios (MRRs) estimated using Poisson regression and adjusted for calendar period, age, sex, family history of psychiatric disorders, maternal age at time of birth, paternal age at time of birth, parental education status, and parental employment status. Over the course of follow up, which totalled 24.9 million person-years, 5580 cohort members died including 78 individuals with DBDs. The mortality rate per 10,000 person-years was 9.66 for individuals with DBDs compared to 2.22 for those with no diagnosis. This corresponded to a fully adjusted MRR of 2.57 (95% confidence interval 2.04-3.20). Comorbid substance use disorder and attention-deticit/hyperactivity disorder resulted in the highest MRR across all categories. These findings demonstrate the excess mortality associated with DBDs.

【 授权许可】

Free