期刊论文详细信息
NEUROPSYCHOLOGIA 卷:161
Sensory gating is related to positive and disorganised schizotypy in contrast to smooth pursuit eye movements and latent inhibition
Article
Hills, Peter J.1  Vasilev, Martin R.1  Ford, Panarai1  Snell, Lucy1  Whitworth, Emma1  Parsons, Tessa1  Morisson, Rebecca1  Silveira, Abigail1  Angele, Bernhard1 
[1] Bournemouth Univ, Poole, Dorset, England
关键词: Schizophrenia;    Schizotypy;    Schizotypal personality;    Latent inhibition;    Smooth pursuit eye movements;    Sensory gating;    Endophenotypes;   
DOI  :  10.1016/j.neuropsychologia.2021.107989
来源: Elsevier
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【 摘 要 】

Since the characteristics and symptoms of both schizophrenia and schizotypy are manifested heterogeneously, it is possible that different endophenotypes and neurophysiological measures (sensory gating and smooth pursuit eye movement errors) represent different clusters of symptoms. Participants (N = 205) underwent a standard conditioned-pairing paradigm to establish their sensory gating ratio, a smooth-pursuit eye-movement task, a latent inhibition task, and completed the Schizotypal Personality Questionnaire. A Multidimensional Scaling analysis revealed that sensory gating was related to positive and disorganised dimensions of schizotypy. Latent inhibition and prepulse inhibition were not related to any dimension of schizotypy. Smooth pursuit eye movement error was unrelated to sensory gating and latent inhibition, but was related to negative dimensions of schizotypy. Our findings suggest that the symptom clusters associated with two main endophenotypes are largely independent. To fully understand symptomology and outcomes of schizotypal traits, the different subtypes of schizotypy (and potentially, schizophrenia) ought to be considered separately rather than together.

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