Active inference and the anatomy of oculomotion

NEUROPSYCHOLOGIA

卷:111

Article

Parr, Thomas¹  Friston, Karl J.¹ 

[1] UCL, Inst Neurol, Wellcome Trust Ctr Neuroimaging, 12 Queen Sq, London WC1N 3BG, England

关键词: Free energy;    Saccades;    Oculomotor;    Brainstem;    Predictive coding;    Active inference;   

DOI  :  10.1016/j.neuropsychologia.2018.01.041

来源: Elsevier

【 摘 要 】

Given that eye movement control can be framed as an inferential process, how are the requisite forces generated to produce anticipated or desired fixation? Starting from a generative model based on simple Newtonian equations of motion, we derive a variational solution to this problem and illustrate the plausibility of its implementation in the oculomotor brainstem. We show, through simulation, that the Bayesian filtering equations that implement 'planning as inference' can generate both saccadic and smooth pursuit eye movements. Crucially, the associated message passing maps well onto the known connectivity and neuroanatomy of the brainstem and the changes in these messages over time are strikingly similar to single unit recordings of neurons in the corresponding nuclei. Furthermore, we show that simulated lesions to axonal pathways reproduce eye movement patterns of neurological patients with damage to these tracts.

【 授权许可】

Free