Amygdala control of emotion-induced forgetting and remembering: Evidence from Urbach-Wiethe disease

NEUROPSYCHOLOGIA

卷:45

Article

Hurlemann, Rene ; Wagner, Michael ; Hawellek, Barbara ; Reich, Harald ; Pieperhoff, Peter ; Amunts, Katrin ; Oros-Peusquens, Ana-Maria ; Shah, Nadim J. ; Maier, Wolfgang ; Dolan, Raymond J.

关键词: emotion;    amygdala;    lesion;    episodic memory;    amnesia;    hypermnesia;   

DOI  :  10.1016/j.neuropsychologia.2006.08.027

来源: Elsevier

【 摘 要 】

When presented in a neutral context, emotional items interfere with episodic encoding of temporally contiguous non-emotional items, resulting in dissociable valence-dependent retrograde and arousal -dependent anterograde modulatory effects. By studying two rare patients with congenital lipoid proteinosis (Urbach-Wiethe) and a focal disease emphasis on the basolateral amygdala (BLA), we demonstrate that this bidirectional modification of episodic encoding by emotion depends on the integrity of the amygdala, as both retrograde and anterograde modulatory effects are absent. Our findings implicate the amygdala in a neural circuitry that orchestrates rapid retrograde and anterograde regulation of episodic memory access upon criteria of behavioral significance. (c) 2006 Elsevier Ltd. All rights reserved.

【 授权许可】

Free