White-matter vascular lesions correlate with alpha EEG sources in mild cognitive impairment

NEUROPSYCHOLOGIA

卷:46

Review

Babiloni, Claudio^2,3,4  Frisoni, Giovanni B.^1,4  Pievani, Michela¹  Toscano, Leonia⁵  Del Percio, Claudio¹  Geroldi, Cristina¹  Eusebi, Fabrizio⁶  Miniussi, Carlo^1,7  Rossini, Paolo A.^1,4,8 

[1] IRCCS S Giovanni Dio FBF, I-25125 Brescia, Italy

[2] Univ Foggia, Dept Biomed Sci, Foggia, Italy

[3] IRCCS San Raffaele Pisana, Casa di Cura San Raffaele Cassino, Rome, Italy

[4] Osp FBF, Dept Neurosci, AFaR, Rome, Italy

[5] Univ Sapienza, Dept Physiol & Pharmacol, Rome, Italy

[6] Neuromed IRCCS, Isernia, Italy

[7] Univ Brescia, Brescia, Italy

[8] Univ Campus Biomed, Neurol Clin, Rome, Italy

关键词: mild cognitive impairment (MCI);    Alzheimer's disease (AD);    electroencephalography (EEG);    magnetic resonance imaging (MRI);    white-matter vascular lesion;    Wahlund scale;   

DOI  :  10.1016/j.neuropsychologia.2008.03.021

来源: Elsevier

【 摘 要 】

It is an open issue if vascular and Alzheimer's disease (AD) lesions represent additive factors in the development of mild cognitive impairment (MCI), as a preclinical stage of Alzheimer's disease (AD) at group level. In the present study, we tested the hypothesis that electroencephalographic (EEG) alpha rhythms, which are affected (i.e. decreased in amplitude) by AD processes, are relatively preserved in MCI subjects in whom the cognitive decline is mainly explained by white-matter vascular load. Resting EEG was recorded in 40 healthy elderly (Nold), 80 MCI, and 40 AD subjects. In the MCI subjects, white-matter vascular load was quantified based on MRI (0-30 Wahlund visual rating scale). EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha 1 (8-10.5 Hz), alpha 2 (10.5-13 Hz), beta 1 (13-20 Hz), and beta 2 (20-30 Hz). Low resolution electromagnetic source tomography (LORETA) was used for EEG source analysis. As expected, we observed that alpha I sources in parietal, occipital, and temporal areas were lower in amplitude in the AD and MCI subjects than in the Nold subjects, whereas the amplitude of wide delta sources was higher in the AD than in the Nold and MCI subjects. As novel results, the amplitude of parietal, occipital, and temporal alpha I sources was higher in the MCI V+ (high vascular load; N= 42; MMSE = 26) than MCI V-group (low vascular load; N= 37; MMSE = 26.7). Furthermore, a weak but significant (p < 0.05) positive statistical correlation was found between the parietal alpha 1 sources and the score of Wahlund scale across all MCI subjects (i.e. the more severe white-matter lesions, the higher parietal alpha source power). The present results are in line with the additive model of cognitive impairment postulating that this arises as the sum of neurodegenerative and cerebrovascular lesions. (c) 2008 Elsevier Ltd. All rights reserved.

【 授权许可】

Free