Let thy left brain know what thy right brain doeth: Inter-hemispheric compensation of functional deficits after brain damage

NEUROPSYCHOLOGIA

卷:93

Article

Bartolomeo, Paolo^1,2,3  Thiebaut de Schotten, Michel^1,2,3,4 

[1] Sorbonne Univ, INSERM, CNRS UMR 7225, U1127, F-75013 Paris, France

[2] Univ Pierre & Marie Curie Paris 6, UMRS 1127, Inst Cerveau & Moelle Epiniere ICM, F-75013 Paris, France

[3] Salpetriere Hosp, AP HP, Dept Neurol, IFR 70, Paris, France

[4] Brain & Spine Inst, Frontlab, Brain Connect & Behav, Paris, France

关键词: Brain;    Hemisphere;    Stroke;    Recovery;    Asymmetry;    Neurogenesis;    White matter;    Connections;    Phenotypes;    Stratification;    Longitudinal;   

DOI  :  10.1016/j.neuropsychologia.2016.06.016

来源: Elsevier

【 摘 要 】

Recent evidence revealed the importance of inter-hemispheric communication for the compensation of functional deficits after brain damage. This review summarises the biological consequences observed using histology as well as the longitudinal findings measured with magnetic resonance imaging methods in brain damaged animals and patients. In particular, we discuss the impact of post-stroke brain hyperactivity on functional recovery in relation to time. The reviewed evidence also suggests that the proportion of the preserved functional network both in the lesioned and in the intact hemispheres, rather than the simple lesion location, determines the extent of functional recovery. Hence, future research exploring longitudinal changes in patients with brain damage may unveil potential biomarkers underlying functional recovery. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

Free