Grey and white matter substrates of action naming

NEUROPSYCHOLOGIA

卷:131

Article

Akinina, Yu^1,2  Dragoy, O.^1,3  Ivanova, M., V^1,4,5  Iskra, E., V^1,6  Soloukhina, O. A.¹  Petryshevsky, A. G.⁶  Fedina, O. N.^6,7  Turken, A. U.⁵  Shklovsky, V. M.⁶  Dronkers, N. F.^4,5,8 

[1] Natl Res Univ Higher Sch Econ, Ctr Language & Brain, 21-4 Staraya Basmannaya St,Off 510, Moscow 105066, Russia

[2] Univ Groningen, Grad Sch Humanities, POB 716, NL-9700 AS Groningen, Netherlands

[3] Fed Ctr Cerebrovasc Pathol & Stroke, Dept Med Rehabil, 1-10 Ostrovityanova St, Moscow 117342, Russia

[4] Univ Calif Berkeley, Dept Psychol, 2121 Berkeley Way, Berkeley, CA 94704 USA

[5] VA Northern Calif Hlth Care Syst, Ctr Aphasia & Related Disorders, 150 Muir Rd 126R, Martinez, CA 94553 USA

[6] Ctr Speech Pathol & Neurorehabil, 20 Nikoloyamskaya St, Moscow 109240, Russia

[7] Med & Nucl Technol Ltd, 1-133 Akad Kurchatova St, Moscow 123182, Russia

[8] Univ Calif Davis, Dept Neurol, Sacramento, CA 95817 USA

关键词: Picture naming;    Verbs;    VLSM;    Aphasia;    White-matter tracts;   

DOI  :  10.1016/j.neuropsychologia.2019.05.015

来源: Elsevier

【 摘 要 】

Despite a persistent interest in verb processing, data on the neural underpinnings of verb retrieval are fragmentary. The present study is the first to analyze the contributions of both grey and white matter damage affecting verb retrieval through action naming in stroke. We used voxel-based lesion-symptom mapping (VLSM) with an action naming task in 40 left-hemisphere stroke patients. Within the grey matter, we revealed the critical involvement of the left precentral and inferior frontal gyri, insula, and parts of basal ganglia. An overlay of white matter tract probability masks on the VLSM lesion map revealed involvement of left-hemisphere long and short association tracts with terminations in the frontal areas; and several projection tracts. The involvement of these structures is interpreted in the light of existing picture naming models, semantic control processes, and the embodiment cognition framework. Our results stress the importance of both cortico-cortical and cortico-subcortical networks of language processing.

【 授权许可】

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