The relationships between the amount of spared tissue, percent signal change, and accuracy in semantic processing in aphasia

NEUROPSYCHOLOGIA

卷:84

Article

Sims, Jordyn A.¹  Kapse, Kushal¹  Glynn, Peter²  Sandberg, Chaleece³  Tripodis, Yorghos⁴  Kiran, Swathi¹ 

[1] Boston Univ, Aphasia Res Lab, Sargent Coll Hlth & Rehabil Sci, 635 Commonwealth Ave, Boston, MA 02215 USA

[2] Northwestern Univ, Feinberg Sch Med, 303 Chicago Ave, Chicago, IL 60611 USA

[3] Penn State Univ, Coll Hlth & Human Dev, Ford Bldg, State Coll, PA 16801 USA

[4] Boston Univ, Sch Publ Hlth, Dept Biostat, 801 Massachusetts Ave, Boston, MA 02118 USA

关键词: Aphasia;    fMRI;    Language recovery;    Lesion mapping;    Regions of interest (ROI);   

DOI  :  10.1016/j.neuropsychologia.2015.10.019

来源: Elsevier

【 摘 要 】

Recovery from aphasia, loss of language following a cerebrovascular incident (stroke), is a complex process involving both left and right hemispheric regions. In our study, we analyzed the relationships between semantic processing behavioral data, lesion size and location, and percent signal change from functional magnetic resonance imaging (fMRI) data. This study included 14 persons with aphasia in the chronic stage of recovery (six or more months post stroke), along with normal controls, who performed semantic processing tasks of determining whether a written semantic feature matched a picture or whether two written words were related. Using region of interest (ROI) analysis, we found that left inferior frontal gyrus pars opercularis and pars triangularis, despite significant damage, were the only regions to correlate with behavioral accuracy. Additionally, bilateral frontal regions including superior frontal gyrus, middle frontal gyrus, and anterior cingulate appear to serve as an assistive network in the case of damage to traditional language regions that include inferior frontal gyrus, middle temporal gyrus, supramarginal gyrus, and angular gyrus. Right hemisphere posterior regions including right middle temporal gyrus, right supramarginal gyrus, and right angular gyrus are engaged in the case of extensive damage to left hemisphere language regions. Additionally, right inferior frontal gyrus pars orbitalis is presumed to serve a monitoring function. These results reinforce the importance of the left hemisphere in language processing in aphasia, and provide a framework for the relative importance of left and right language regions in the brain. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

Free