Enhanced distraction by magnocellular salience signals in schizophrenia

NEUROPSYCHOLOGIA

卷:56

Article

Leonard, Carly J.^1,2  Robinson, Benjamin M.³  Hahn, Britta³  Gold, James M.³  Luck, Steven J.^1,2 

[1] Univ Calif Davis, Ctr Mind & Brain, Davis, CA 95618 USA

[2] Univ Calif Davis, Dept Psychol, Davis, CA 95618 USA

[3] Univ Maryland, Sch Med, Maryland Psychiat Res Ctr, Baltimore, MD 21201 USA

关键词: Schizophrenia;    Visual attention;    Magnocellular;    Eye movements;    Visual search;    Attentional capture;   

DOI  :  10.1016/j.neuropsychologia.2014.02.011

来源: Elsevier

【 摘 要 】

Research on schizophrenia has provided evidence of both impaired attentional control and dysfunctional magnocellular sensory processing. The present study tested the hypothesis that these impairments may be related, such that people with schizophrenia would be differentially distracted by stimuli that strongly activate the magnocellular pathway. To accomplish this, we used a visual attention paradigm from the basic cognitive neuroscience literature designed to assess the capture of attention by salient but irrelevant stimuli. Participants searched for a target shape in an array of non-target shapes. On some trials, a salient distractor was presented that either selectively activated the parvocellular system (parvo-biased distractors) or activated both the magnocellular and parvocellular systems (magno+parvo distractors). For both manual reaction times and eye movement measures, the magno+parvo distractors captured attention more strongly than the parvo-biased distractors in people with schizophrenia, but the opposite pattern was observed in matched healthy control participants. These results indicate that attentional control deficits in schizophrenia may arise, at least in part, by means of an interaction with magnocellular sensory dysfunction. (C) 2014 Elsevier Ltd. All rights reserved.

【 授权许可】

Free