Clinical practice of rTMS reveals a functional dissociation between agency and hallucinations in schizophrenia

NEUROPSYCHOLOGIA

卷:47

Article

Jardri, Renaud^1,2  Delevoye-Turrell, Yvonne^3,4  Lucas, Bernard⁴  Pins, Delphine¹  Bulot, Virginie⁴  Delmaire, Christine⁵  Thomas, Pierre^1,4  Delion, Pierre^1,2  Goeb, Jean-Louis^1,2 

[1] Univ Lille Nord France, CNRS, UMR 8160, CHRU Lille, F-59037 Lille, France

[2] CHRU Lille, Serv Psychiat Enfant & Adolescent, Hop Fontan, F-59037 Lille, France

[3] Univ Lille Nord France, EA1059, F-59653 Villeneuve Dascq, France

[4] CHRU Lille, Serv Psychiat Adulte, Hop Fontan, F-59037 Lille, France

[5] CHRU Lille, Serv Neuroradiol, Hop Salengro, F-59037 Lille, France

关键词: Self-awareness;    Agency;    Hallucinations;    Schizophrenia;    Motor control;    rTMS;    fMRI;   

DOI  :  10.1016/j.neuropsychologia.2008.08.006

来源: Elsevier

【 摘 要 】

We report here the case of a hospitalized 11 year-old boy (YP) with a positive diagnosis of 'Childhood Onset Schizophrenia'. YP experienced verbal-auditory hallucinations, a delusion of alien control and hetero-aggressive behaviour. Antipsychotic drugs were unsuccessful and furthermore provoked severe acute dystonia. fMRI-guided rTMS applied over several cortical regions provided the means to reveal for the first time a functional dissociation between auditory-verbal hallucinations and agency. These results demonstrate the efficacy of rTMS for young patients suffering from drug-resistant hallucinations but they furthermore question the physiopathology of the hallucinatory process by suggesting that agency and hallucinations may be sub-served by different neural networks. (C) 2008 Elsevier Ltd. All rights reserved.

【 授权许可】

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