Daily life activities in patients with Alzheimer's disease or semantic dementia: Multitasking assessment

NEUROPSYCHOLOGIA

卷:150

Article

Jarry, Christophe¹  Osiurak, Francois^2,3  Baumard, Josselin⁴  Lesourd, Mathieu⁵  Coiffard, Clemence¹  Lucas, Charlene¹  Merck, Catherine⁶  Etcharry-Bouyx, Frederique^1,7  Chauvire, Valerie⁷  Belliard, Serge^6,8  Moreaud, Olivier^9,10  Croisile, Bernard¹¹  Gall, Didier Le^1,7 

[1] Nantes Univ, Lab Psychol Pays La Loire, LPPL EA 4638, SFR Confluences,UNIV Angers,Maison Rech Germaine, 5 Bis Blvd Lavoisier, F-49045 Angers 01, France

[2] Univ Lyon, EA 3082, Lab Etud Mecanismes Cognitifs, Lyon, France

[3] Inst Univ France, Paris, France

[4] Normandie Univ, UNIROUEN, CRFDP, EA7475, Rouen, France

[5] Univ Bourgogne Franche Comte, Lab Psychol, EA3188, Besancon, France

[6] Ctr Hosp Univ Pontchaillou, Serv Neurol, CMRR, Rennes, France

[7] CHU Angers, Dept Neurol, Unite Neuropsychol, Angers, France

[8] Lab Neuropsychol, Unite INSERM, U1077, Caen, France

[9] CHU Grenoble, Pole Psychiat & Neurol, CMRR Grenoble Arc Alpin, Grenoble, France

[10] Lab Psychol & Neurocognit CNRS UMR 5105, Grenoble, France

[11] Hop Neurol & Neurochirurg P Wertheimer, Serv Neuropsychol, Bron, France

关键词: Daily life activities;    Multitasking;    Semantic memory;    Executive functions;    Episodic memory;    Tool use;   

DOI  :  10.1016/j.neuropsychologia.2020.107714

来源: Elsevier

【 摘 要 】

The aim of the present study was to compare patients with mild to moderate Alzheimer's disease (AD) or semantic dementia (SD) on their cognitive processes and the severity of their daily life activity impairments. Three types of tasks were administered to patients (SD = 15; AD = 31) and 30 healthy controls (HC): 1) informant-based scales and questionnaires, 2) a neuropsychological assessment exploring executive functions, episodic and semantic memory, and 3) a new original test featuring multi-step naturalistic actions and multitasking: the Sequential Daily Life Multitasking (SDLM). We predicted that patients with AD would mainly exhibit task perplexity, associated with episodic and executive deficits on the SDLM, while the behavior of patients with SD would mostly be characterized by object perplexity, associated with semantic memory deficits. Results showed that patients with AD or SD were impaired across all neuropsychological tests, particularly episodic memory in AD and semantic memory in SD. General performance on the SDLM also appeared dramatically impaired in both patient groups, and correlated with results of questionnaires about instrumental activities and memory impairments. However, specific qualitative measurements on the SDLM did not allow us to pinpoint different patterns of errors and behavior in patients with AD versus SD. We suggest that the inability of patients in both groups to perform the SDLM may derive from a constellation of disorders or else from more subtle impairment of cognitive and cognitive processes that requires further exploration.

【 授权许可】

Free