Adaptation to cognitive context and item information in the medial temporal lobes

NEUROPSYCHOLOGIA

卷:50

Article

Diana, Rachel A.¹  Yonelinas, Andrew P.²  Ranganath, Charan^2,3 

[1] Virginia Polytech Inst & State Univ, Dept Psychol, Blacksburg, VA 24060 USA

[2] Univ Calif Davis, Dept Psychol, Davis, CA 95616 USA

[3] Univ Calif Davis, Ctr Neurosci, Davis, CA 95616 USA

关键词: Parahippocampal cortex;    Perirhinal cortex;    Adaptation;    Context;    Memory;   

DOI  :  10.1016/j.neuropsychologia.2012.07.035

来源: Elsevier

【 摘 要 】

The medial temporal lobes (MTL) play an essential role in episodic memory, and accumulating evidence indicates that two MTL subregions-the perirhinal (PRc) and parahippocampal (PHc) cortices-might have different functions. According to the binding of item and context theory (Diana, Yonelinas, & Ranganath, 2007; Eichenbaum, Yonelinas, & Ranganath, 2007), PRc is involved in processing item information, the target of memory encoding, whereas PHc is involved in processing context information, peripheral information that identifies the circumstances of the episode. Here, we used functional magnetic resonance imaging (fMRI) adaptation to test the roles of different MTL subregions in the processing of item and context information. Participants were scanned while viewing a series of objects. Each object was presented with a unique semantic encoding question that elicited a salient cognitive context. The object picture, the encoding question, both, or neither were immediately repeated. We found that PRc activity was sensitive to repetition of the object but not the encoding question whereas PHc activity was sensitive to repetition of the encoding question but not the object. These data are consistent with the idea that the PRc and PHc are differentially involved in the representation of item and context information and additionally suggest that the role of the PHc extends to nonspatial, cognitive context information. (C) 2012 Elsevier Ltd. All rights reserved.

【 授权许可】

Free