Trajectories of cognitive function in dementia-free subjects: Radiation Effects Research Foundation Adult Health Study

JOURNAL OF THE NEUROLOGICAL SCIENCES

卷:351

Article

Yamada, Michiko^1,2  Landes, Reid D.^1,2  Mimori, Yasuyo³  Nagano, Yoshito⁴  Sasaki, Hideo⁵ 

[1] Radiat Effects Res Fdn, Dept Clin Studies, Minami Ku, Hiroshima 7320815, Japan

[2] Radiat Effects Res Fdn, Dept Stat, Minami Ku, Hiroshima 7320815, Japan

[3] Hiroshima Int Univ, Dept Phys Therapy, Higashi Ku, Hiroshima 7392695, Japan

[4] Hiroshima Univ, Dept Clin Neurosci & Therapeut, Minami Ku, Hiroshima 7340037, Japan

[5] Yasuda Womens Univ, Dept Nutr Sci, Asaminami Ku, Hiroshima 7310153, Japan

关键词: Cognition;    Cohort study;    Non-demented subjects;    Aging;    Education;    Gender;   

DOI  :  10.1016/j.jns.2015.02.050

来源: Elsevier

【 摘 要 】

Objectives: To investigate associations between age, sex, education, and birth cohort and global cognitive decline among a population that would most likely not progress to dementia. Methods: A total of 1538 dementia-free subjects aged 60 to 80 years in 1992 were followed up through 2011 without dementia occurrence. We assessed cognitive function using the Cognitive Ability Screening Instrument (CASI). Using stepwise-like model selection procedure, we built mixed-effects models for initial cognition and longitudinal cognition. Results: Initial CASI scores for younger age and more years of formal education were higher than those for older and less education. Sex did not show a significant effect In the longitudinal analysis, cognitive decline became more rapid with increasing age. Sex and education did not modify the degree of deterioration with age. CASI scores were higher for younger cohorts and men due to differences in education levels. Conclusion: Among dementia-free subjects, age is an important predictor of cognitive function level and cognitive decline. Education level affects cognitive function level, but did not affect cognitive decline. The results have implications not only for elucidation of the aging process, but also for reference in dementia screening. (C) 2015 Elsevier B.V. All rights reserved.

【 授权许可】

Free