JOURNAL OF THE NEUROLOGICAL SCIENCES | 卷:395 |
Concurrent Guillain-Barre syndrome, transverse myelitis and encephalitis post-Zika: A case report and review of the pathogenic role of multiple arboviral immunity | |
Review | |
Mancera-Paez, Oscar1,2  Roman, Gustavo C.3,4,5  Pardo-Turriago, Rodrigo1  Rodriguez, Yhojan6  Anaya, Juan-Manuel6  | |
[1] Univ Nacl Colombia, Hosp Univ Nacl, Dept Neurol, Fac Med, Bogota, Colombia | |
[2] Houston Methodist Hosp, David Cabello Int Alzheimer Dis Scholarship Fund, Houston, TX USA | |
[3] Methodist Neurol Inst, Dept Neurol, Houston, TX USA | |
[4] Houston Methodist Hosp, Inst Acad Med, Houston Methodist Res Inst, Houston, TX USA | |
[5] Cornell Univ, Dept Neurol, Weill Cornell Med Coll, New York, NY 10021 USA | |
[6] Univ Rosario, Sch Med & Hlth Sci, Ctr Autoimmune Dis Res CREA, Bogota, Colombia | |
关键词: Zika virus; Guillain-Barre syndrome; Transverse myelitis; Acute disseminated encephalomyelitis; Post-infectious encephalitis; Colombia; | |
DOI : 10.1016/j.jns.2018.09.028 | |
来源: Elsevier | |
【 摘 要 】
We review post-infectious and post-vaccination neurological syndromes involving peripheral and central nervous system (CNS) and report an illustrative case of simultaneous occurrence of Guillain-Barre syndrome (GBS), confirmed by nerve conduction velocities, plus MRI-demonstrated transverse myelitis (TM) and acute encephalitis [acute disseminated encephalomyelitis] (ADEM + GBS) affecting a 24-year-old woman from Cucuta, Colombia, who developed acute Zika virus (ZIKV) infection confirmed by serum reverse transcriptase-polymerase chain reaction (RT-PCR) and convalescent ZIKV IgG antibodies. With intensive care treatment, respiratory support, steroids, and intravenous immunoglobulin (IVIg), patient survived with residual flaccid paraparesis. She had preexisting immunity against Chikungunya virus (CHIKV) and Dengue virus (DENV) acquired before the arrival of ZIKV in Colombia. From reports in the Caribbean, Central and South America we review 19 cases of ZIKV-associated TM, encephalitis and ADEM occurring after a mean latent period of 10.5 days (range 1-96) post-infection. Although GBS and ADEM are usually considered post-infectious and associated with development of antibodies against peripheral nerve and CNS epitopes, we postulate that our case of ADEM + GBS is para-infectious, induced by acute ZIKV neurotropism boosted by active immunity against other arboviruses. Animal models of ZIKV demonstrated strong viral neurotropism enhanced by passive immunity with antibodies against arboviruses such as West Nile virus, CHIKV, or DENV. These considerations are relevant to prevent potential ZIKV vaccine-induced reactions involving central and peripheral nervous system.
【 授权许可】
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【 预 览 】
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10_1016_j_jns_2018_09_028.pdf | 660KB | download |