Hormone levels are related to functional compensation in prolactinomas: A resting-state fMRI study

JOURNAL OF THE NEUROLOGICAL SCIENCES

卷:411

Article

Yao, Shun^1,2,3  Lin, Pan⁴  Vera, Matthew³  Akter, Farhana^5,6  Zhang, Ru-Yuan⁷  Zeng, Ailiang^8,9  Golby, Alexandra J.^3,10  Xu, Guozheng²  Tie, Yanmei³  Song, Jian² 

[1] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Neurosurg, Ctr Pituitary Tumor Surg, Guangzhou, Peoples R China

[2] Southern Med Univ, Gen Hosp Chinese PLA Cent Theater Command, Dept Neurosurg, 627 Wuluo Rd, Wuhan 430070, Peoples R China

[3] Harvard Med Sch, Brigham & Womens Hosp, Dept Neurosurg, Hale BTM 8016G,60 Fenwood Rd, Boston, MA 02115 USA

[4] Hunan Normal Univ, Cognit & Human Behav Key Lab Hunan Prov, Dept Psychol, Changsha, Peoples R China

[5] Harvard Univ, Fac Arts & Sci, Cambridge, MA 02138 USA

[6] Harvard Med Sch, Massachussets Gen Hosp, Canc Ctr, Boston, MA 02115 USA

[7] Univ Minnesota Twin Cities, Dept Neurosci, Ctr Magnet Resonance Res, Minneapolis, MN USA

[8] Nanjing Med Univ, Affiliated Hosp 1, Dept Neurosurg, Nanjing, Peoples R China

[9] Harvard Med Sch, Brigham & Womens Hosp, Dept Neurol, Boston, MA 02115 USA

[10] Harvard Med Sch, Brigham & Womens Hosp, Dept Radiol, Boston, MA 02115 USA

关键词: Hormone levels;    Prolactinomas;    Pituitary tumor;    Functional connectivity;    Brain compensation;    Resting-state fMRI;   

DOI  :  10.1016/j.jns.2020.116720

来源: Elsevier

【 摘 要 】

Prolactinomas are tumors of the pituitary gland, which overproduces prolactin leading to dramatic fluctuations of endogenous hormone levels throughout the body. While it is not fully understood how endogenous hormone disorders affect a patient's brain, it is well known that fluctuating hormone levels can have negative neuropsychological effects. Using resting-state functional magnetic resonance imaging (rs-fMRI), we investigated whole-brain functional connectivity (FC) and its relationship with hormone levels in prolactinomas. By performing seed-based FC analyses, we compared FC metrics between 33 prolactinoma patients and 31 healthy controls matched for age, sex, and hand dominance. We then carried out a partial correlation analysis to examine the relationship between FC metrics and hormone levels. Compared to healthy controls, prolactinoma patients showed significantly increased thalamocortical and cerebellar-cerebral FC. Endogenous hormone levels were also positively correlated with increased FC metrics, and these hormone-FC relationships exhibited sex differences in prolactinoma patients. Our study is the first to reveal altered FC patterns in prolactinomas and to quantify the hormone-FC relationships. These results indicate the importance of endogenous hormones on functional compensation of the brain in patients with prolactinomas.

【 授权许可】

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