Delayed auditory feedback simulates features of nonfluent primary progressive aphasia

JOURNAL OF THE NEUROLOGICAL SCIENCES

卷:347

Article

Maruta, Carolina^1,2,3  Makhmood, Sonya³  Downey, Laura E.³  Golden, Hannah L.³  Fletcher, Phillip D.³  Witoonpanich, Pirada³  Rohrer, Jonathan D.³  Warren, Jason D.³ 

[1] Univ Lisbon, Inst Mol Med, P-1699 Lisbon, Portugal

[2] Univ Lisbon, Fac Med, P-1699 Lisbon, Portugal

[3] UCL, UCL Inst Neurol, Dementia Res Ctr, London, England

关键词: Delayed auditory feedback;    Altered auditory feedback;    Dementia;    Progressive aphasia;    Language;    Dorsal pathway;   

DOI  :  10.1016/j.jns.2014.09.039

来源: Elsevier

【 摘 要 】

The pathophysiology of nonfluent primary progressive aphasia (nfvPPA) remains poorly understood. Here, we compared quantitatively speech parameters in patients with nfvPPA versus healthy older individuals under altered auditory feedback, which has been shown to modulate normal speech output. Patients (n = 15) and healthy volunteers (n = 17) were recorded while reading aloud under delayed auditory feedback [DAF] with latency 0,50 or 200 ms and under DAF at 200 ms plus 0.5 octave upward pitch shift. DAF in healthy older individuals was associated with reduced speech rate and emergence of speech sound errors, particularly at latency 200 ms. Up to a third of the healthy older group under DAF showed speech slowing and frequency of speech sound errors within the range of the nfvPPA cohort Our findings suggest that (in addition to any anterior, primary language output disorder) these key features of nfvPPA may reflect distorted speech input signal processing, as simulated by DAF. DAF may constitute a novel candidate pathophysiological model of posterior dorsal cortical language pathway dysfunction in nfvPPA. (C) 2014 The Authors. Published by Elsevier B.V.

【 授权许可】

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