Modulatory effects of cognitive exertion on regional functional connectivity of the salience network in women with ME/CFS: A pilot study

JOURNAL OF THE NEUROLOGICAL SCIENCES

卷:422

Article

Manca, Riccardo¹  Khan, Katija²  Mitolo, Micaela³  Marco, Matteo De¹  Grieveson, Lynsey⁴  Varley, Rosemary⁵  Wilkinson, Iain D.⁶  Venneri, Annalena¹ 

[1] Univ Sheffield, Dept Neurosci, Beech Hill Rd, Sheffield S10 2RX, S Yorkshire, England

[2] Univ West Indies, Dept Clin Med Sci, Psychiat Unit, St Augustine Campus, St Augustine, Trinidad Tobago

[3] IRCCS Ist Sci Neurol Bologna, Diagnost Funz Neuroradiol, Bologna, Italy

[4] Univ Sheffield, Fac Med Dent & Hlth, Sheffield, S Yorkshire, England

[5] UCL, Dept Language & Cognit, London, England

[6] Univ Sheffield, Acad Unit Radiol, Sheffield, S Yorkshire, England

关键词: Chronic fatigue;    Pain;    Cognitive effort;    Post-exertional malaise;    Functional connectivity;    Salience network;    Insula;   

DOI  :  10.1016/j.jns.2021.117326

来源: Elsevier

【 摘 要 】

Background: A common symptom of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is postexertional malaise (PEM). Various brain abnormalities have been observed in patients with ME/CFS, especially in insular and limbic areas, but their link with ME/CFS symptoms is still unclear. This pilot study aimed at investigating the association between PEM in ME/CFS and changes in functional connectivity (FC) of two main networks: the salience network (SN) and the default-mode network (DMN). Methods: A total of 16 women, 6 with and 10 without ME/CFS, underwent clinical and MRI assessment before and after cognitive exertion. Resting-state FC maps of 7 seeds (3 for the SN and 4 for the DMN) and clinical measures of fatigue, pain and cognition were analysed with repeated-measure models. FC-symptom change associations were also investigated. Results: Exertion induced increases in fatigue and pain in patients with ME/CFS compared to the control group, while no changes were found in cognitive performance. At baseline, patients showed altered FC between some DMN seeds and frontal areas and stronger FC between all SN seeds and left temporal areas and the medulla. Significantly higher FC increases in patients than in controls were found only between the right insular seed and frontal and subcortical areas; these increases correlated with worsening of symptoms. Conclusions: Cognitive exertion can induce worsening of ME/CFS-related symptoms. These changes were here associated with strengthening of FC of the right insula with areas involved in reward processing and cognitive control.

【 授权许可】

Free