Environmental factors and their regulation of immunity in multiple sclerosis

JOURNAL OF THE NEUROLOGICAL SCIENCES

卷:324

Article

Koch, Marcus W.¹ 

[1] Univ Calgary, Dept Clin Neurosci, Calgary, AB T2N 4N1, Canada

关键词: Multiple sclerosis;    Risk factors;    Epidemiology;    Immunology;    Autoimmunity;   

DOI  :  10.1016/j.jns.2012.10.021

来源: Elsevier

【 摘 要 】

Epidemiological and clinical studies have shown that environmental factors such as infections, smoking and vitamin D are associated with the risk of developing multiple sclerosis (MS). Some of these factors also play a role in the MS disease course. We are currently beginning to understand how environmental factors may impact immune function in MS on a cellular and molecular level. Here we review epidemiological, clinical and basic immunological studies on the environmental factors, viral and parasitic infections, smoking, and vitamin D and relate epidemiological findings with their likely pathophysiology in MS. (C) 2012 Elsevier B.V. All rights reserved.

【 授权许可】

Free