Reduced spontaneous sympathetic nerve activity in multiple sclerosis patients

JOURNAL OF THE NEUROLOGICAL SCIENCES

卷:344

Article

Keller, David M.¹  Fadel, Paul J.^2,3  Hamsberger, Melissa A.⁴  Remington, Gina M.⁴  Frohman, Elliot M.^4,5  Davis, Scott L.^4,6 

[1] Univ Texas Arlington, Dept Kinesiol, Arlington, TX 76019 USA

[2] Univ Missouri, Dept Med Pharmacol & Physiol, Columbia, MO USA

[3] Univ Missouri, Dalton Cardiovasc Res Ctr, Columbia, MO USA

[4] Univ Texas SW Med Ctr Dallas, Dept Neurol, Dallas, TX 75390 USA

[5] Univ Texas SW Med Ctr Dallas, Dept Ophthalmol, Dallas, TX 75390 USA

[6] So Methodist Univ, Dept Appl Physiol & Wellness, Dallas, TX 75275 USA

关键词: Muscle sympathetic nerve activity;    Autonomic dysfunction;    Microneurography;    Blood pressure;    Plasma norepinephrine;    Peripheral vasculature;   

DOI  :  10.1016/j.jns.2014.06.053

来源: Elsevier

【 摘 要 】

For the first time, we obtained direct intra-neural measurements of muscle sympathetic nerve activity (MSNA) in relapsing-remitting multiple sclerosis (MS) patients to test the hypothesis that spontaneous resting MSNA is reduced in MS patients compared to age, sex-matched healthy controls. Spontaneous MSNA (microneurography; peroneal nerve), plasma norepinephrine, arterial blood pressure (finger photoplethysmography), and heart rate were measured at rest in three groups: 1) relapsing-remitting MS patients on disease modifying therapy only (MS-DT; n = 6); 2) relapsing-remitting MS patients on disease modifying therapy and medications for MS-related symptoms that are known to effect the central nervous system (MS-DT/ST; n = 5), and 3) healthy age and sex-matched controls (CON; n = 6). Compared to the CON group, MSNA burst frequency (bursts/min) was significantly lower in both MS-DT (P = 0.027) and MS-DT/ST groups (P = 0.003). Similarly, MSNA burst incidence (bursts/100 heartbeats) was significantly reduced in both MS-DT (P = 0.049) and MS-DT/ST groups (P = 0.004) compared to the CON group. Burst frequency and burst incidence were not different between MS-DT and MS-DT/ST groups. Resting plasma norepinephrine was also significantly lower in both MS-DT (P = 0.039) and MS-DT/ST groups (P = 0.021) compared to the CON group. Reduced MSNA may signify an important dysfunction in autonomic control of cardiovascular function in patients with MS. (C) 2014 Elsevier B.V. All rights reserved.

【 授权许可】

Free