Application of an evidence-based, out-patient treatment strategy for COVID-19: Multidisciplinary medical practice principles to prevent severe disease*

JOURNAL OF THE NEUROLOGICAL SCIENCES

卷:426

Review

Frohman, Elliot M.¹  Villemarette-Pittman, Nicole R.²  Rodriguez, Adriana³  Glanzman, Robert⁴  Rugheimer, Sarah⁵  Komogortsev, Oleg⁶  Zamvil, Scott S.^7,8  Cruz, Roberto Alejandro^9,13  Varkey, Thomas C.¹⁰  Frohman, Ashley N.¹¹  Frohman, Audrey R.¹¹  Parsons, Matthew S.^12,14  Konkle, Emily Heckmann¹¹  Frohman, Teresa C.¹ 

[1] Stanford Univ, Sch Med, Lab Neuroimmunol, Stanford, CA 94305 USA

[2] LSU Hlth Sci Ctr New Orleans, Dept Neurol, New Orleans, LA USA

[3] Cook Childrens Med Ctr, Dept Emergency Med, Ft Worth, TX USA

[4] Clene Nanomed Inc, Salt Lake City, UT 84121 USA

[5] Univ Oxford, Dept Phys, Oxford OX1 3PU, England

[6] Texas State Univ, Dept Comp Sci, San Marcos, TX USA

[7] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA

[8] Univ Calif San Francisco, Program Immunol, San Francisco, CA USA

[9] Doctors Hlth Renaissance Hlth Neurol Inst, Dept Neurol, Mcallen, TX USA

[10] Univ Texas Austin, Dell Med Sch, Austin, TX 78712 USA

[11] Frohman Fdn, Austin, TX USA

[12] Yerkes Natl Primate Res Ctr, Div Microbiol & Immunol, Atlanta, GA USA

[13] Univ Texas Rio Grande Valley, Sch Med, Dept Neurol, Edinburg, TX USA

[14] Emory Univ, Dept Pathol & Lab Med, Atlanta, GA 30322 USA

关键词: SARS-CoV-2;    COVID-19;    Bronchiole;    Alveoli;    Pulse oximetry;    Oxygen saturation;    Inflammation;    Gas exchange;    Pulmonary hygiene;    Expectorate;    Mucus clearance;    Postural percussion;    Vibratory sonication;    Respiratory muscle training;    Vitamin D;   

DOI  :  10.1016/j.jns.2021.117463

来源: Elsevier

【 摘 要 】

The COVID-19 pandemic has devastated individuals, families, and institutions throughout the world. Despite the breakneck speed of vaccine development, the human population remains at risk of further devastation. The decision to not become vaccinated, the protracted rollout of available vaccine, vaccine failure, mutational forms of the SARS virus, which may exhibit mounting resistance to our molecular strike at only one form of the viral family, and the rapid ability of the virus(es) to hitch a ride on our global transportation systems, means that we are will likely continue to confront an invisible, yet devastating foe. The enemy targets one of our human physiology's most important and vulnerable life-preserving body tissues, our broncho-alveolar gas exchange apparatus. Notwithstanding the fear and the fury of this microbe's potential to raise existential questions across the entire spectrum of human endeavor, the application of an early treatment intervention initiative may represent a crucial tool in our defensive strategy. This strategy is driven by evidence-based medical practice principles, those not likely to become antiquated, given the molecular diversity and mutational evolution of this very clever world traveler.

【 授权许可】

Free