Vascular dementia

JOURNAL OF THE NEUROLOGICAL SCIENCES

卷:322

Article

Korczyn, Amos D.²  Grinberg, Lea T.^1,3 

[1] Univ Calif San Francisco, Memory & Aging Ctr, Dept Neurol, San Francisco, CA 94143 USA

[2] Tel Aviv Univ, Sackler Sch Med, Ramat Aviv, Israel

[3] Univ Sao Paulo, Sch Med, Aging Brain Study Grp, Dept Pathol, BR-05508 Sao Paulo, Brazil

关键词: Vascular;    Dementia;    Stroke;    Diagnosis;    Neuropathology;    Biomarkers;    Cognitive impairment;   

DOI  :  10.1016/j.jns.2012.03.027

来源: Elsevier

【 摘 要 】

The epidemic growth of dementia causes great concern for the society. It is customary to consider Alzheimer's disease (AD) as the most common cause of dementia, followed by vascular dementia (VaD). This dichotomous view of a neurodegenerative disease as opposed to brain damage caused by extrinsic factors led to separate lines of research in these two entities. Indeed, accumulated data suggest that the two disorders have additive effects and probably interact; however it is still unknown to what degree. Furthermore, epidemiological studies have shown vascular risk factors to be associated with AD. Therefore, a clear distinction between AD and VaD cannot be made in most cases, and is furthermore unhelpful. In the absence of efficacious treatment for the neurodegenerative process, special attention must be given to the vascular component, even in patients with presumed mixed pathology. Symptomatic treatment of VaD and AD is similar, although the former is less effective. For prevention of dementia it is important to treat all factors aggressively, even in stroke survivors who do not show evidence of cognitive decline. In this review, we will give a clinical and pathological picture of the processes leading to VaD and discuss its interaction with AD. (c) 2012 Elsevier B.V. All rights reserved.

【 授权许可】

Free