Altered Cortical Activation in Adolescents With Acute Migraine: A Magnetoencephalography Study

JOURNAL OF PAIN

卷:14

Article

Xiang, Jing^1,3  deGrauw, Xinyao¹  Korostenskaja, Milena^1,4  Korman, Abraham M.¹  O'Brien, Hope L.^1,3  Kabbouche, Marielle A.^1,3  Powers, Scott W.²  Hershey, Andrew D.^1,3 

[1] Cincinnati Childrens Hosp Med Ctr, Div Neurol, Cincinnati, OH 45229 USA

[2] Cincinnati Childrens Hosp Med Ctr, Dept Behav Med & Clin Psychol, Cincinnati, OH 45229 USA

[3] Univ Cincinnati, Coll Med, Dept Neurol, Cincinnati, OH USA

[4] Walt Disney Pavil Florida Hosp Children, Ctr Pediat Res, Comprehens Pediat Epilepsy Ctr, Funct Brain Mapping & Brain Comp Interface Lab, Orlando, FL USA

关键词: Migraine;    magnetoencephalography (MEG);    pediatric;    high-frequency oscillations;    wavelet;   

DOI  :  10.1016/j.jpain.2013.04.009

来源: Elsevier

【 摘 要 】

To quantitatively assess cortical dysfunction in pediatric migraine, 31 adolescents with acute migraine and age- and gender-matched controls were studied using a magnetoencephalography (MEG) system at a sampling rate of 6,000 Hz. Neuromagnetic brain activation was elicited by a finger-tapping task. The spectral and spatial signatures of magnetoencephalography data in 5 to 2,884 Hz were analyzed using Morlet wavelet and beamformers. Compared with controls, 31 migraine subjects during their headache attack phases (ictal) showed significantly prolonged latencies of neuromagnetic activation in 5 to 30 Hz, increased spectral power in 100 to 200 Hz, and a higher likelihood of neuromagnetic activation in the supplementary motor area, the occipital and ipsilateral sensorimotor cortices, in 2,200 to 2,800 Hz. Of the 31 migraine subjects, 16 migraine subjects during their headache-free phases (interictal) showed that there were no significant differences between interictal and control MEG data except that interictal spectral power in 100 to 200 Hz was significantly decreased. The results demonstrated that migraine subjects had significantly aberrant ictal brain activation, which can normalize interictally. The spread of abnormal ictal brain activation in both low- and high-frequency ranges triggered by movements may play a key role in the cascade of migraine attacks. (C) 2013 by the American Pain Society

【 授权许可】

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