Structural Brain Anomalies and Chronic Pain: A Quantitative Meta-Analysis of Gray Matter Volume

JOURNAL OF PAIN

卷:14

Review

Smallwood, Rachel F.^1,2  Laird, Angela R.³  Ramage, Amy E.^4,5  Parkinson, Amy L.^4,6  Lewis, Jeffrey⁷  Clauw, Daniel J.⁸  Williams, David A.⁸  Schmidt-Wilcke, Tobias⁹  Farrell, Michael J.¹⁰  Eickhoff, Simon B.^11,12  Robin, Donald A.^4,6 

[1] Univ Texas Hlth Sci Ctr San Antonio, Joint Program Biomed Engn, San Antonio, TX 78229 USA

[2] Univ Texas San Antonio, San Antonio, TX USA

[3] Florida Int Univ, Dept Phys, Miami, FL 33199 USA

[4] Univ Texas Hlth Sci Ctr San Antonio, Res Imaging Inst, San Antonio, TX 78229 USA

[5] Univ Texas Hlth Sci Ctr San Antonio, Dept Psychiat, San Antonio, TX 78229 USA

[6] Univ Texas Hlth Sci Ctr San Antonio, Dept Neurol, San Antonio, TX 78229 USA

[7] NINDS, Behav Neurol Unit, NIH, Bethesda, MD 20892 USA

[8] Univ Michigan, Chron Pain & Fatigue Res Ctr, Ann Arbor, MI 48109 USA

[9] Ruhr Univ Bochum, Bergmannsheil, Dept Neurol, Bochum, Germany

[10] Univ Melbourne, Florey Neurosci Inst, Melbourne, Vic 3010, Australia

[11] Univ Dusseldorf, Inst Clin Neurosci & Med Psychol, D-40225 Dusseldorf, Germany

[12] Res Ctr Julich, Inst Neurosci & Med INM 1, Julich, Germany

关键词: Chronic pain;    voxel-based morphometry;    meta-analysis;    gray matter volume;   

DOI  :  10.1016/j.jpain.2013.03.001

来源: Elsevier

【 摘 要 】

The diversity of chronic pain syndromes and the methods employed to study them make integrating experimental findings challenging. This study performed coordinate-based meta-analyses using voxel-based morphometry imaging results to examine gray matter volume (GMV) differences between chronic pain patients and healthy controls. There were 12 clusters where GMV was decreased in patients compared with controls, including many regions thought to be part of the pain matrix of regions involved in pain perception, but also including many other regions that are not commonly regarded as pain-processing areas. The right hippocampus and parahippocampal gyrus were the only regions noted to have increased GMV in patients. Functional characterizations were implemented using the BrainMap database to determine which behavioral domains were significantly represented in these regions. The most common behavioral domains associated with these regions were cognitive, affective, and perceptual domains. Because many of these regions are not classically connected with pain and because there was such significance in functionality outside of perception, it is proposed that many of these regions are related to the constellation of comorbidities of chronic pain, such as fatigue and cognitive and emotional impairments. Further research into the mechanisms of GMV changes could provide a perspective on these findings. Perspective: Quantitative meta-analyses revealed structural differences between brains of individuals with chronic pain and healthy controls. These differences may be related to comorbidities of chronic pain. (C) 2013 by the American Pain Society

【 授权许可】

Free