Green Light Antinociceptive and Reversal of Thermal and Mechanical Hypersensitivity Effects Rely on Endogenous Opioid System Stimulation

JOURNAL OF PAIN

卷:22

Article

Martin, Laurent F.^1,2  Moutal, Aubin¹  Cheng, Kevin¹  Washington, Stephanie M.²  Calligaro, Hugo⁶  Goel, Vasudha⁷  Kranz, Tracy²  Largent-Milnes, Tally M.¹  Khanna, Rajesh^1,2,3,4,5  Patwardhan, Amol^1,2,5,8  Ibrahim, Mohab M.^1,2,5,8 

[1] Univ Arizona, Coll Med, Dept Pharmacol, Tucson, AZ 85724 USA

[2] Univ Arizona, Coll Med, Dept Anesthesiol, 1501 North Campbell Dr,POB 245050, Tucson, AZ 85724 USA

[3] Univ Arizona, Coll Med, Neurosci Grad Interdisciplinary Program, Tucson, AZ 85724 USA

[4] Univ Arizona Hlth Sci, Ctr Innovat Brain Sci, Tucson, AZ USA

[5] Univ Arizona, Comprehens Pain & Addict Ctr, Tucson, AZ 85724 USA

[6] Salk Inst Biol Studies, Regulatory Biol Lab, San Diego, CA USA

[7] Univ Minnesota, Dept Anesthesiol, Med Sch, Minneapolis, MN 55455 USA

[8] Univ Arizona, Coll Med, Dept Neurosurg, Tucson, AZ 85724 USA

关键词: Key Words;    Phototherapy;    green light;    GP120;    neuropathic pain;    endogenous opioids;   

DOI  :  10.1016/j.jpain.2021.05.006

来源: Elsevier

【 摘 要 】

Benefits of phototherapy were characterized in multiple diseases including depression, circadian rhythm disruptions, and neurodegeneration. Studies on migraine and fibromyalgia patients revealed that green light-emitting diodes (GLED) exposure provides a pragmatic and safe therapy to manage chronic pain. In rodents, GLED reversed hypersensitivity related to neuropathic pain. However, little is known about the underlying mechanisms of GLED efficacy. Here, we sought to understand how green light modulates the endogenous opioid system. We first characterized how exposure to GLED stimulates release of b-endorphin and proenkephalin in the central nervous system of male rats. Moreover, by individually editing each of the receptors, we found that m- and d-opioid receptors are required for green light's antinociceptive effect in nay center dot ve rats and a model of HIVinduced peripheral neuropathy. We investigated how GLED could increase pain thresholds, and explored its potential in reversing hypersensitivity in a model of HIV-related neuropathy. Through behavioral and gene editing approaches, we identified that green light provides antinociception via modulation of the endogenous opioid system in the spinal cord. This work identifies a previously unknown mechanism by which GLED can improve pain management. Clinical translation of these results will advance the development of an innovative therapy devoid of adverse effects. Perspective: Development of new pain management therapies, especially for HIV patients, is crucial as long-term opioid prescription is not recommended due to adverse side effects. Green light addresses this necessity. Characterizing the underlying mechanisms of this potentially groundbreaking and safe antinociceptive therapy will advance its clinical translation. (c) 2021 by United States Association for the Study of Pain, Inc.

【 授权许可】

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