Pregabalin Suppresses Nociceptive Behavior and Central Sensitization in a Rat Trigeminal Neuropathic Pain Model

JOURNAL OF PAIN

卷:14

Article

Cao, Ye^1,2  Wang, Hua²  Chiang, Chen-Yu²  Dostrovsky, Jonathan O.^2,3  Sessle, Barry J.^2,3 

[1] Peking Univ, Sch & Hosp Stomatol, Dept Prosthodont, Beijing 100871, Peoples R China

[2] Univ Toronto, Fac Dent, Toronto, ON M5G 1G6, Canada

[3] Univ Toronto, Fac Med, Dept Physiol, Toronto, ON M5G 1G6, Canada

关键词: Pregabalin;    allodynia;    central sensitization;    trigeminal neuropathic pain;   

DOI  :  10.1016/j.jpain.2012.11.005

来源: Elsevier

【 摘 要 】

The aim of this study was to determine whether pregabalin affects nociceptive behavior and central sensitization in a trigeminal neuropathic pain model. A partial infraorbital nerve transection (p-IONX) or sham operation was performed in adult male rats. Nociceptive withdrawal thresholds were tested with von Frey filaments applied to the bilateral vibrissal pads pre- and postoperatively. On postoperative day 7, the behavioral assessment was conducted before and at 30, 60, 120, and 180 minutes after and 24 hours after pregabalin (.1, 1, 10, 100 mg/kg intraperitoneally) or saline injection. The effects of pregabalin or saline were also examined on the mechanoreceptive field and response properties of nociceptive neurons recorded in the medullary dorsal horn at postoperative days 7 to 10. Reduced with-drawal thresholds reflecting bilateral mechanical allodynia were observed in p-IONX rats until postoperative day 28, but not in sham-operated rats. At postoperative day 7, pregabalin significantly and dose-dependently reversed the reduced mechanical withdrawal thresholds in p-IONX rats. Pregabalin also attenuated central sensitization of the neurons, as reflected in reversal of their reduced activation threshold, increased responses to pinch/pressure, and enhanced stimulus-response function. This study provides the first documentation that pregabalin attenuates the mechanical allodynia and central sensitization that characterize this trigeminal neuropathic pain model, and supports its clinical use for treating craniofacial neuropathic pain. Perspective: Trigeminal nerve injury in rats produced facial mechanical hypersensitivity and trigeminal central sensitization of medullary dorsal horn neurons that were markedly attenuated by systemically administered pregabalin, suggesting its potential clinical utility for orofacial neuropathic pain. (C) 2013 by the American Pain Society

【 授权许可】

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