Increase in circadian variation after continuous-flow ventricular assist device implantation

JOURNAL OF HEART AND LUNG TRANSPLANTATION

卷:29

Article

Slaughter, Mark S.¹  Ising, Michael S.²  Tamez, Daniel³  O'Driscoll, Gerry⁴  Voskoboynikov, Neil³  Koenig, Steven C.²  Giridharan, Guruprasad A.² 

[1] Univ Louisville, Div Thorac & Cardiovasc Surg, Dept Surg, Louisville, KY 40202 USA

[2] Univ Louisville, Dept Bioengn, Louisville, KY 40202 USA

[3] HeartWare Inc, Miami Lakes, FL USA

[4] Royal Perth Hosp, Perth, WA, Australia

关键词: heart failure;    circadian rhythm;    ventricular assist devices;    diurnal variation;   

DOI  :  10.1016/j.healun.2009.12.006

来源: Elsevier

【 摘 要 】

The circadian rhythm of varying blood pressure and heart rate is attenuated or absent in patients with severe heart failure. In 28 patients supported by a left ventricular assist device (LVAD) for at least 30 days, a restoration of the circadian rhythm was demonstrated by a consistent nocturnal decrease, and then increase, of the LVAD flow while at a constant LVAD speed. The return of the circadian rhythm has implications for cardiac recovery, and the observation indicates that the continuous-flow LVAD has an intrinsic automatic response to physiologic demands. J Heart Lung Transplant 2010;29:695-7 (C) 2010 International Society for Heart and Lung Transplantation. All rights reserved.

【 授权许可】

Free