Development of de novo aortic valve incompetence in patients with the continuous-flow HeartWare ventricular assist device

JOURNAL OF HEART AND LUNG TRANSPLANTATION

卷:35

Article

Bhagra, Sai¹  Bhagra, Catriona¹  Oezalp, Faruk^2,3  Butt, Tanveer^2,3  Ramesh, B. C.^2,3  Parry, Gareth^2,3  Roysam, Chandrika^2,3  Woods, Andrew²  Robinson-Smith, Nicola²  Wrightson, Neil^2,3  MacGowan, Guy A.^1,2,3,4  Schueler, Stephan^2,3 

[1] Freeman Rd Hosp, Dept Cardiol, Newcastle Upon Tyne NE7 7DN, Tyne & Wear, England

[2] Freeman Rd Hosp, Dept Cardiothorac Surg, Newcastle Upon Tyne NE7 7DN, Tyne & Wear, England

[3] Freeman Rd Hosp, Dept Cardiopulmonaty Transplantat, Newcastle Upon Tyne NE7 7DN, Tyne & Wear, England

[4] Newcastle Univ, Inst Genet Med, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

关键词: HVAD;    HeartWare;    VAD;    aortic regurgitation;    aortic incompetence;    aortic root;    echocardiogram;   

DOI  :  10.1016/j.healun.2015.10.022

来源: Elsevier

【 摘 要 】

BACKGROUND: In this study we investigated the development of aortic incompetence (AI) and change in aortic root and left ventricular dimensions after implantation of the continuous-flow HeartWare ventricular assist device (HVAD) in our adult patient cohort. METHODS: A retrospective analysis of serial echocardiograms was performed on patients implanted with an HVAD between July 2009 and July 2013. Data from echocardiograms performed before and at 1 and 2 years (+/- 3 months) were analyzed. Patients with native aortic valves (AoVs) with no previous intervention and HVAD in situ for >= 6 months were included. RESULTS: A total of 73 HVADs in 71 patients with a mean duration of support of 624 +/- 359 days were included in our study. One patient developed moderate AI at 1 year (1.9%). Mild or greater AI was more likely in those with a closed or intermittently opening AoV at 1 year (p = 0.005). Aortic annulus dimensions increased significantly at 1 and 2 years, regardless of extent of AI. At 2 years, in those with mild or worse AI, the sinuses of Valsalva were also larger (p = 0.002). Left ventricular end-diastolic dimension (LVEDD) was significantly reduced in those with no or trace AI at 1 and 2 years (p = 0.012 and p = 0.008, respectively), but remained unchanged in those with AI at both time-points. CONCLUSIONS: The development of more than mild AI is rare in HVAD patients at our center. When encountered, it is more common with a closed AoV. Dilation of the aortic annulus, and root dilation in those with mild or more AI, is seen with HVAD support over time. (C) 2016 International Society for Heart and Lung Transplantation. All rights reserved.

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