Interval versus continuous training in lung transplant candidates: A randomized trial

JOURNAL OF HEART AND LUNG TRANSPLANTATION

卷:31

Article

Gloeckl, Rainer¹  Halle, Martin^2,3  Kenn, Klaus¹ 

[1] Schoen Klin Berchtesgadener Land, Dept Resp Med & Sports Therapy, D-83471 Schoenau, Germany

[2] Tech Univ Munich, Dept Internal Med, Div Prevent Rehabil & Sports Med, Munich, Germany

[3] MHA, Munich, Germany

关键词: chronic obstructive pulmonary disease;    rehabilitation;    lung transplantation;    exercise;    training;    interval;   

DOI  :  10.1016/j.healun.2012.06.004

来源: Elsevier

【 摘 要 】

BACKGROUND: Interval (IT) and continuous training (CT) represent well-established exercise modalities in patients with moderate to severe chronic obstructive pulmonary disease (COPD). However, their effects and feasibility in patients with end-stage COPD remain unclear. METHODS: Sixty patients (53 +/- 6 years, 53% women) being evaluated for lung transplantation where randomly assigned either to IT (n = 30, cycling at 100% peak work rate for 30 seconds alternating with 30 seconds of rest) or CT (n = 30, cycling at 60% of peak work rate) during a 3-week inpatient rehabilitation program. Both exercise protocols yielded an equivalent amount of total work. Patients had a mean forced expiratory volume at 1 second (FEV1) of 25% +/- 8% of predicted value. RESULTS: Patients in both groups achieved similar clinically relevant improvements in 6-minute walking distance of 35 +/- 29 meters for IT and 36 +/- 43 meters for CT, with a between-group difference of 0.3 meters (95% confidence interval, -18.2 to 18.8). Changes in lung function parameters were not significant. Perceived intensity of dyspnea was significantly (p < 0.05) lower in IT (Borg 6.2 +/- 1.8) compared with CT (Borg 7.1 +/- 1.7). Patients required a median of 5 unintended breaks (interquartile range, 2-28) during IT exercise and 29 (interquartile range, 6-68) during CT (p < 0.001). CONCLUSIONS: IT is associated with a lower intensity of dyspnea during exercise and fewer unintended breaks but achieves similar improvements in exercise capacity compared with CT in pre-lung transplant COPD patients. J Heart Lung Transplant 2012;31:934-41 (C) 2012 International Society for Heart and Lung Transplantation. All rights reserved.

【 授权许可】

Free