Poly-arginine conjugated triarylmethyl radical as intracellular spin label

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:26

Article

Driesschaert, Benoit^1,2  Bobko, Andrey A.^1,2  Eubank, Timothy D.^1,3  Samouilov, Alexandre⁴  Khramtsov, Valery V.^1,2  Zweier, Jay L.⁴ 

[1] W Virginia Univ, Robert C Byrd Hlth Sci Ctr, In Vivo Multifunct Magnet Resonance Ctr, Morgantown, WV 26506 USA

[2] W Virginia Univ, Sch Med, Dept Biochem, Morgantown, WV 26506 USA

[3] W Virginia Univ, Sch Med, Dept Microbiol Immunol & Cell Biol, Morgantown, WV 26506 USA

[4] Ohio State Univ, Wexner Med Ctr, Davis Heart & Lung Res Inst, 460 West 12th Ave,BRT 0390, Columbus, OH 43210 USA

关键词: EPR;    TAM;    Poly-arginine;    Radical;    Cyclic voltammetry;   

DOI  :  10.1016/j.bmcl.2016.02.048

来源: Elsevier

【 摘 要 】

Stable triarylmethyl radicals are ideal spin labels used for biomedical electron paramagnetic resonance applications. Previously reported structures exhibit polar charged functions for water solubilization preventing them from crossing the cell membrane. We report the synthesis of a triarylmethyl radical conjugated to poly-arginine peptide allowing intracellular delivery of the paramagnetic label. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

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