Parallel chemoenzymatic synthesis of sialosides containing a C5-diversified sialic acid

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:19

Article

Cao, Hongzhi¹  Muthana, Saddam¹  Li, Yanhong¹  Cheng, Jiansong¹  Chen, Xi¹ 

[1] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA

关键词: Carbohydrates;    Chemoenzymatic synthesis;    Enzymes;    Parallel synthesis;    Sialic acid;    Sialosides;   

DOI  :  10.1016/j.bmcl.2009.08.078

来源: Elsevier

【 摘 要 】

A convenient chemoenzymatic strategy for synthesizing sialosides containing a C5-diversified sialic acid was developed. The alpha 2,3- and alpha 2,6-linked sialosides containing a 5-azido neuraminic acid synthesized by a highly efficient one-pot three-enzyme approach were converted to C5 ''-amino sialosides, which were used as common intermediates for chemical parallel synthesis to quickly generate a series of sialosides containing various sialic acid forms. (C) 2009 Elsevier Ltd. All rights reserved.

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