Bis-anthracenyl isoxazolyl amides have enhanced anticancer activity

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:19

Article

Gajewski, Mariusz P.¹  Beall, Howard¹  Schnieder, Mark¹  Stranahan, Sarah M.³  Mosher, Michael D.^3,4  Rider, Kevin C.^2,3  Natale, Nicholas R.^1,3 

[1] Univ Montana, Dept Biomed & Pharmaceut Sci, Missoula, MT 59812 USA

[2] Univ Montana, Core Lab Neuromol Prod, Missoula, MT 59812 USA

[3] Univ Idaho, Dept Chem, Moscow, ID 83844 USA

[4] Univ Nebraska Kearney, Dept Chem, Kearney, NE 68849 USA

关键词: Anthracene;    Antitumor;    Fluorescence;    Glioma;    G-quadruplex DNA;    Isoxazole;    SNB-19;   

DOI  :  10.1016/j.bmcl.2009.06.019

来源: Elsevier

【 摘 要 】

Dimeric analogs of Anthracenyl Isoxazole Amides (AIMs) (the designation AIM is in honor of the memory of Professor Albert I. Meyers) were prepared and dimer 6 exhibited the highest efficacy to date for this class of anti-tumor compounds against the human glioma Central Nervous System cell line SNB-19. (C) 2009 Elsevier Ltd. All rights reserved.

【 授权许可】

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