Quantitative screening of EGF receptor-binding peptides by using a peptide library with multiple fluorescent amino acids as fluorescent tags

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:20

Article

Kitamatsu, Mizuki¹  Yamamoto, Takahiro¹  Futami, Midori¹  Sisido, Masahiko¹ 

[1] Okayama Univ, Grad Sch Nat Sci & Technol, Dept Med & Bioengn, Kita Ku, Okayama 7000082, Japan

关键词: Peptide;    Peptide library;    Peptide screening;    EGFR;    Fluorescent amino acid;   

DOI  :  10.1016/j.bmcl.2010.08.078

来源: Elsevier

【 摘 要 】

EGF receptor-binding peptides could be found by a peptide screening method using fifteen fluorescent amino acids as fluorescent tags. Of 225 peptides, we found an 8-mer peptide containing a dipeptide unit, Y-F, which was the strongest binding peptide to the EGF receptor. (c) 2010 Elsevier Ltd. All rights reserved.

【 授权许可】

Free